Clinical Trials Logo
  1. Home
  2. Oral Squamous Cell Carcinoma
  3. NCT05791149

Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity — EPSACO  

Biomarkers Clinical Trial

Official title:
Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity

Clinical Trial Summary

Head and neck squamous cell carcinoma (HNSCC) are malignant tumors originating from the epithelial mucosa of the upper aerodigestive tract. The oral cavity is the most frequent location of HNSCC (oral squamous cell carcinoma: OSCC). Tobacco use and alcohol consumption are the greatest risk factors. The Hauts de France region has one of the highest incidence rates of OSCC. The overall survival of patients with OSCC remains low, with a 5-year overall survival rate of around 60%. In addition to the oncological prognosis, OSCCs and their treatment have a significant impact on the quality of life of patients. An early diagnosis of OSCC is recommended, but it remains difficult. It can be for example challenging to diagnose OSCC in a context of oral premalignant lesions. Identifying objective biomarkers of malignancy would be an advantage and would allow better progress in the field of precision medicine and surgery for these tumors. The investigators propose to establish the diagnostic use of an optimized DNA methylation profile detected in the saliva of OSCC patients by comparing these epigenetic marks before and after tumor resection. The investigators will construct a consolidated signature of 4 genes whose DNA is subject to methylation and gene expression is restricted to cancer cells, by crossing TCGA analysis with single-cell analysis (single-cell RNA sequencing). The investigators propose to analyse DNA methylation of the corresponding genes in the saliva of n=30 OSCC patients recruited for primary surgical resection in the Department of Maxillofacial Surgery vs controls. In addition, the investigators will examine the methylation profiles before / after complete excisional surgery of OSCC. This pilot study will aim to validate the analysis of DNA methylation markers in saliva of OSCC, with the aim of improving the diagnostic precision of OSCC and, secondly, to compare these markers before and after treatment by primary surgery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05791149
Study type Interventional
Source Centre Hospitalier Universitaire, Amiens
Contact Zuzana SAIDAK, PhD
Phone 03 22 08 70 84
Email saidak.zuzana@chu-amiens.fr
Status Recruiting
Phase N/A
Start date March 3, 2022
Completion date October 2023
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT05095324 - The Biomarker Prediction Model of Septic Risk in Infected Patients
Recruiting NCT05548933 - Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia
Active, not recruiting NCT03926572 - Acute Decompensation of Pulmonary Hypertension N/A
Recruiting NCT05372159 - Vanderbilt Memory and Aging Project
Completed NCT03173586 - Sugar Sweetened Beverage Intake and Biomarkers of Cardiometabolic Risk in US Women N/A
Completed NCT04554628 - Early Prediction of Acute Kidney Injury Among Patients Admitted to Surgical ICU N/A
Terminated NCT03250312 - The Effects of OMT on the Expression Patterns of Immune Cell Biomarkers N/A
Recruiting NCT04666766 - Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers N/A
Completed NCT04573543 - The Role of Immune Semaphorins in NAFLD
Completed NCT03193671 - Evaluation and Implementation of New Biomarkers and Algorithms for Diagnosis of Ovarian Cysts/Tumors in the Pelvis N/A
Recruiting NCT06047132 - PREDICTIVE ABILITY OF A PANEL OF BIOMARKERS IN SALIVA IN HEALTHY AND PERIODONTALLY AFFECTED SUBJECTS
Completed NCT05361460 - Patients Experiences of Early Postoperative Cognition
Recruiting NCT05706194 - Early Neuroprognostication After OHCA
Recruiting NCT05138731 - Metabolomics Profiling of Coronary Heart Disease
Recruiting NCT06446895 - Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries
Not yet recruiting NCT04563000 - Impact of Vitamin C on Biomarkers of Neurologic Injury in Survivors of Cardiac Arrest Phase 2
Completed NCT05138692 - Biomarkers and Outcome 1 and 10-15 Years After Severe Traumatic Brain Injury
Completed NCT02247999 - Improving Cervical Cancer Screening Among HIV-Infected Women in India
Active, not recruiting NCT02732301 - Postoperative Gastrointestinal Dysfunction After Cardiac Surgery - Occurrence and Search for Biomarkers
Not yet recruiting NCT03269019 - Thrombotic Biomarkers to Predict Thrombosis in Heparin-induced Thrombocytopenia N/A