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NCT05708209 Clinical Trial

The Long Non Coding MALAT1 as a Potential Salivary Diagnostic Biomarker in Oral Squamous Cell Carcinoma Through Targeting mi RNA 124

Oral Squamous Cell Carcinoma Clinical Trial

Official title:
The Long Non Coding MALAT1 as a Potential Salivary Diagnostic Biomarker in Oral Squamous Cell Carcinoma Through Targeting mi RNA 124

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05708209
Other study ID # 19038219038211012
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 1, 2022
Est. completion date January 1, 2023

Study information
Verified date September 2023
Source Fayoum University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Objective: is to determine the diagnostic accuracy of lncRNA MALAT1 as a potential salivary biomarker of OSCC as well as assessment of the salivary expression level of miRNA 124 which is targeted by MALAT1. Materials and Methods: Saliva Samples were collected for the quantitative determination of salivary "MALAT1 and mi RNA -124" using quantitative Real-time Polymerase Chain Reaction technique for the two study groups, Group A: 20 patients with a diagnosis suggestive of OSCC and Group B: 20 age-and-sex-matched healthy individuals, as normal controls.

Description:

Materials and Methods: Saliva Samples were collected for the quantitative determination of salivary "MALAT1 and mi RNA -124" using quantitative Real-time Polymerase Chain Reaction technique for the two study groups, Group A: 20 patients with a diagnosis suggestive of OSCC and Group B: 20 age-and-sex-matched healthy individuals, as normal controls.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date January 1, 2023
Est. primary completion date December 1, 2022
Accepts healthy volunteers
Gender All
Age group 20 Years to 65 Years
Eligibility Inclusion Criteria: - The study included patients with OSCC and healthy controls of both sexes. Exclusion Criteria: - Patients having systemic diseases such as; liver diseases, cardiovascular disease, nervous system, pulmonary, renal, endocrine, gastrointestinal disorders, or other types of cancer were excluded.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Egypt Rania Hassan Shalby Giza

Sponsors (1)
Lead Sponsor Collaborator
Fayoum University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary quantitative determination of salivary non-coding RNAs "MALAT1 quantitative determination of salivary non-coding RNAs "MALAT1 using quantitative Real-time Polymerase Chain Reaction technique (qRT-PCR) in the whole unstimulated saliva 2 months
Secondary quantitative determination of salivary mi RNA -124" quantitative determination of salivary mi RNA -124" using quantitative Real-time Polymerase Chain Reaction technique (qRT-PCR) in the whole unstimulated saliva 2 months
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