Vasodilation Clinical Trial
Official title:
Non-invasive Imaging of Human Gingival Microcirculation: Effect of Nitric Oxide
The aim of this study is to observe the mechanism of spreading vasodilatation on human healthy gingiva. Nitric-oxide donor solutions in lower and higher concentration are used to trigger the vasoactivity.
Spatial regulation of gingival microcirculation has not been revealed yet. Although this
could be an important mechanism to protect gingiva as it is exposed to mechanical, chemical,
thermal etc. irritation during whole life. It is especially important during flap surgery.
Laser Speckle Contrast Imaging (LSCI) is novel non-invasive method with high spatio-temporal
resolution, therefore it allows us to study remote effect of local vasodilation such as
spreading vasodilation in human gingiva.
The vasodilatator nitric-oxide (NO) donor will be used to trigger remote effect on gingiva.
NO donor solutions will be applied in 1 mg/ml and 8 mg/ml nitroglycerin concentrations.
Solution will be dropped on the gingiva at tooth 12 in a fabricated leakage proof well
attached to 2mm above the marginal gingiva. The change on blood flow will be monitor at the
test well with surrounding gingival area spanning 3 tooth and at the contralateral side by
LSCI.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03680638 -
The Effect of Antioxidants on Skin Blood Flow During Local Heating
|
Phase 1 | |
Active, not recruiting |
NCT06454084 -
Investigation of Endothelium-dependent Vasodilation in Human Gingiva
|
N/A | |
Recruiting |
NCT05997732 -
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
|
Phase 4 | |
Recruiting |
NCT06117007 -
Effects of Betalains on Cardiovascular Health and Quality of Life
|
N/A | |
Completed |
NCT03659864 -
The Role of Eicosanoids in the Cardiovascular Actions of Inhaled Nanoparticles
|
N/A | |
Completed |
NCT03459027 -
Nitrate Supplementation and Muscle Blood Flow
|
N/A | |
Recruiting |
NCT04255160 -
Impact of Estradiol on Endothelial Function in Peri-Menopausal Women
|
Phase 4 | |
Recruiting |
NCT05522075 -
Reducing Blood Pressure in Mid-life Adult Binge Drinkers
|
N/A | |
Completed |
NCT00184886 -
The Influence of Methotrexate on the Metabolism and Vascular Effects of Adenosine in Humans
|
N/A | |
Completed |
NCT02095873 -
Healthy Aging Through Functional Food
|
Phase 1/Phase 2 | |
Completed |
NCT02292342 -
An Investigation of the Dose-dependent Vascualr Effects of (-)-Epicatechin in Healthy Men
|
Phase 0 | |
Completed |
NCT00901745 -
Interaction of Apelin and Angiotensin in the Human Forearm Circulation
|
N/A | |
Not yet recruiting |
NCT06290713 -
Vasodilator and Exercise Study for DMD (VASO-REx)
|
Phase 2 | |
Completed |
NCT02265107 -
Effects of Exercise Training on Vascular Endothelial Function of Patients Submitted to Coronary Artery Bypass Graft
|
N/A | |
Recruiting |
NCT05219799 -
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
|
Early Phase 1 | |
Completed |
NCT03622060 -
Intraarterial Nitroglycerin Versus Nicardipine and Radial Artery Occlusion
|
Phase 3 | |
Not yet recruiting |
NCT06417177 -
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
|
Early Phase 1 | |
Completed |
NCT01618071 -
Vascular Effects of Triglyceride-rich Lipoproteins
|
N/A | |
Completed |
NCT03190304 -
The Effect of Neprilysin (LCZ696) on Exercise Tolerance in Patients With Heart Failure
|
Phase 4 | |
Completed |
NCT04928183 -
The Impact of Carbon Monoxide and Altitude on Vascular Function
|
N/A |