Colorectal Cancer Clinical Trial
Official title:
Postoperative Oral and Intestinal Flora Changes in Patients With Colorectal Cancer and the Relationship Between These Changes and Prognosis
Specific oral microbiome has been found to contribute to the development of colorectal cancer. We speculate that specific oral microbiota related to colorectal cancer relapse after curative treatment. This study aim to discover if any difference of oral microbiota exist in patients who suffer from cancer relapse compared with patients who do not. Finally develop patient-centred programmes of surveillance protocols base on microbiota analysis.
Colorectal cancer is a major cause of cancerrelated deaths and the third most commonly
diagnosed cancer worldwide.Current estimates indicate that 20-30% of those who undergo
treatment will experience recurrence and 35% of all patients will die within 5 years.
The human colon plays host to a diverse and metabolically complex community of
microorganisms. While the specific oral microbiome has been found to contribute to the
development of colorectal cancer. Investigators speculate that specific oral microbiota
related to colorectal cancer relapse after curative treatment.
Patients are routinely offered surveillance in order to detect disease recurrence at an
early, asymptomatic stage, with the intention of improving survival. Nevertheless,
controversy continues to surround the optimal surveillance protocols. Investigators aim to
discover if any difference of oral microbiota is exist in patients who suffer from relapse
compared with patients who do not.
Future surveillance after colorectal cancer treatment should focus on risk-stratification.
Finally investigators will develop patient-centred programmes of surveillance protocols base
on microbiota analysis.
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