Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma

Oral Cancer Clinical Trial

Official title:

Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03877159
• Other study ID #: 232080
• Status: Recruiting
• Start date: November 11, 2017
• Est. completion date: January 30, 2021

Study information

• Verified date: July 2020
• Source: Guy's and St Thomas' NHS Foundation Trust
• Contact: Robert Kennedy, BSc PhD BDS
• Phone: 07815501088
• Email: robert.kennedy[@]kcl.ac.uk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Control of cell death is frequently disrupted in cancer resulting in overgrowth of tumour cells. Caspase-8 is a key enzyme involved in controlling cell death. This study examines the importance of caspase-8 in oral cancer.

Description:

Control of cell death is frequently disrupted in cancer resulting in overgrowth of tumour cells. The caspase family of enzymes are the key performers of controlled cell death and caspase-8 is frequently mutated in oral cancer. This study will perform DNA sequencing to determine if the gene is wild-type (not mutated). The abundance of inactive (uncleaved) and active (cleaved) caspase-8 will be determined. The levels of the proteins that caspase-8 interacts with (including caspase-3) will be determined. Results will be correlated with tumour stage, patient outcome and the presence of immune cells and other microscopic features. This will improve the understanding of the importance of caspase-8 in oral cancer.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: January 30, 2021
• Est. primary completion date: January 30, 2021
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Oral cancer

• Sufficient follow up data

Exclusion Criteria:

• Patient has indicated that they do not wish their tissue to be used for research.

• . The quantity or quality of tissue is too little or poor to provide adequate material without significant reserve.

• The material contains bone.

Related Conditions & MeSH terms

• Carcinoma, Squamous Cell
• Mouth Neoplasms
• Oral Cancer

Intervention

Other:
• There is no intervention.
There is no intervention. This is a retrospective study analysing archived tumour samples.

Locations

Country	Name	City	State
United Kingdom	Robert Kennedy	London

Sponsors (1)

Lead Sponsor	Collaborator
Guy's and St Thomas' NHS Foundation Trust

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Caspase-8 activity in oral cancer and its impact on disease progression	Molecular analysis of caspase-8 activity will be undertaken and correlated with tumour features and outcome.	Up to 3 years