Oral Cancer Clinical Trial
Official title:
Dual-time PET/CT and Sentinel Node Diagnostics Preoperatively in Patients With Oral Cancer
In this study, the investigators want to pre-operatively scan patients who do not have any
clinically suspicion of metastases with an 18F-FDG-PET/CT whole body scan , where after they
go to lymphoscintigraphy incl. SPECT/CT and sentinel node biopsy. Material from the oral
cancer and, after permission of each patient, also normal oral tissue will be analyzed
molecular-biologically. Also a blood sample will be analyzed for molecular tumor markers.
The investigators want to see if PET/CT is able to detect any signs of sub-clinically
metastases. Besides, the investigators want to fusion PET/CT with SPECT/CT data from the
lymphoscintigraphy study and improve our PET/CT scanning with a dual-time PET scan of the
head-and-neck region.
These patients are normally preoperatively sent to a CT scan of the thorax and abdomen; in
this study, this CT is replaced by a wholebody PET/CT scan. Afterwards, the patients goes to
sentinel node lymphoscintigraphy and then to operation.
By combining biomarkers and molecular imaging in patients with a clinically T1/T2N0M0 oral
cancer, we want to characterize the tumor physiologically and correlate these physiological
features to the clinical appearance of the cancer.
Aims of the study:
- can PET/CT in this patient group metastases with consequently change of treatment?
- can fusion of SPECT/CT and PET/CT with calculation of standardized uptake value (SUV)
indicate, how much tumor tissue there should be in a positive sentinel node to be
detected by PET?
- can dual-time PET scanning better determine lymph node metastases, than single-time PET
scanning?
- correlation between SUV in PET with molecular-biological findings both in the primary
tumor and in metastases
;
Observational Model: Case-Only, Time Perspective: Prospective
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