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Optical Coherence Tomography clinical trials

View clinical trials related to Optical Coherence Tomography.

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NCT ID: NCT06436482 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Research of Endobronchial Optical Coherence Tomography in Pre-COPD

EBOCTIPCOPD
Start date: March 1, 2023
Phase:
Study type: Observational

The pre-stage of Chronic Obstructive Pulmonary Disease (Pre-COPD) is challenging to diagnose. However, identifying Pre-COPD is a crucial step in the prevention and management of COPD. Endobronchial optical coherence tomography showed the value of diagnosis in Pre-COPD and COPD in previous researchs.

NCT ID: NCT06339021 Not yet recruiting - Clinical trials for ST Elevation Myocardial Infarction

OCT or Angiography Guided De-escalation of DAPT

Start date: April 1, 2024
Phase: Early Phase 1
Study type: Interventional

Optical coherence tomography (OCT) offers a high-resolution intravascular imaging modality to accurately assess vessel and lumen geometry and identify the hallmark of a culprit lesion including plaque disruption and thrombus. In addition, the incorporation of the MLD MAX algorithm into daily practice guides an efficient and easily-memorable workflow for optimized OCT-guided percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Regarding the antithrombotic therapy after revascularization, the 2023 ESC guidelines recommend the P2Y12 receptor inhibitor de-escalation (i.e. switching from ticagrelor to clopidogrel) in ACS patients may be considered as an alternative strategy to the default treatment regimen in order to reduce the risk of bleeding events. Based on the above conclusions, we designed a single-center, prospective, randomized controlled, exploratory study trial to evaluate whether the utility of OCT for guiding PCI with DES followed by antiplatelet de-escalation therapy could further reduce the stent-induced intimal hyperplasia of STEMI patients after stent implantation.

NCT ID: NCT06273722 Not yet recruiting - Clinical trials for Basal Cell Carcinoma

D-OCT for Detection and Subtyping of BCC: a Diagnostic Cohort Study

Start date: April 1, 2024
Phase:
Study type: Observational

The current gold standard for diagnosing basal cell carcinoma (BCC) is the histopathological examination of biopsy specimen. However, non-invasive imaging modalities such as optical coherence tomography (OCT) may replace biopsy if BCC presence and its subtype can be established with high confidence. Subtype differentiation is crucial; while superficial BCCs (sBCC) can be treated topically, nodular (nBCC) and infiltrative BCCs (iBCC) require excision. Dynamic OCT (D-OCT) is a functionality integrated within the OCT device, enabling the visualization of vascular structures through speckle variance. Descriptive studies have unveiled vascular shapes and patterns associated with BCC and its respective subtypes. These findings suggest that D-OCT could contribute to the accuracy of BCC detection and subtyping. Yet comparative clinical studies between OCT and D-OCT are lacking. In the proposed diagnostic cohort study, we aim to assess whether D-OCT assessment is superior to OCT in terms of accuracy for BCC detection and subtyping.

NCT ID: NCT06043622 Recruiting - Clinical trials for Optical Coherence Tomography

Normative Database of Healthy Subject Vascular Density Using Spectralis Heidelberg® Optical Coherence Tomography Angiography

COPENBASE
Start date: June 12, 2023
Phase: N/A
Study type: Interventional

Optical coherence tomography angiography (OCT-A) is a determinant progress to study retinal and choroidal vasculature without using a dye injection. OCT-A yields interesting results in different pathologies such as diabetes mellitus, age-related macular degeneration, hypertension blood pressure, particularly by affecting vascular density. Normative database are necessary to compare OCT-A parameters between patients and controls. However, OCT-A devices from different manufactures may give different values for the same subject. It seems to be obvious that each OCT-A device should have its own normative database. In the literature, OCT-A normative databases are developing using different types of devices, but none is available for Heidelberg OCT-A in Caucasians. The purpose of this project is to create a normative database of retinal microvascularisation using Spectralis Heidelberg optical coherence tomography angiography (OCT-A) ® in normal controls.

NCT ID: NCT06040073 Not yet recruiting - Clinical trials for Optical Coherence Tomography

Natural History of Coronary Atherosclerosis

NASCENT
Start date: October 1, 2023
Phase:
Study type: Observational

The present study sought to explore the predictive value of radial wall strain (RWS, derived solely from angiograms) for coronary artery lesion progression compared with lesion vulnerability assessed by optical coherence tomography (OCT). The lesion progression at 1 year was defined as an increase of ≥20% in diameter stenosis based on quantitative coronary angiography (QCA) evaluation.

NCT ID: NCT05856786 Recruiting - Myopia Clinical Trials

To Study the Effects of Refractive Surgery on OCT Measurements in the Eye

Start date: June 1, 2024
Phase:
Study type: Observational

Corrective eye surgeries, such as Lasik, are widely used to correct focusing problems such as myopia, or nearsightedness. Often these patients develop other conditions like myopic maculopathy or glaucoma which require monitoring with optical coherence tomography (OCT). Since OCT is a light-based test and changes the refractive status of the eye (in the cornea or the lens), it can potentially affect the results of the OCT measurements but has not been sufficiently studied. This pilot study aims at studying the potential change in OCT parameters in the eye after undergoing such surgery.

NCT ID: NCT05817279 Recruiting - Clinical trials for Basal Cell Carcinoma

AI-aided Optical Coherence Tomography for the Detection of Basal Cell Carcinoma

Start date: April 10, 2023
Phase:
Study type: Observational

Basal cell carcinoma (BCC) is the most common form of cancer among the Caucasian population. A BCC diagnosis is commonly establish by means of an invasive punch biopsy (golden standard). Optical coherence tomography (OCT) is a safe non-invasive diagnostic modality which may replace biopsy if an OCT assessor is able to establish a high confidence BCC diagnosis. Hence, for clinical implementation of OCT, diagnostic certainty should be as high as possible. Artificial intelligence in the form of a clinical decision support system (CDSS) may improve the diagnostic certainty of newly trained OCT assessors by highlighting suspicious areas on OCT scans and by providing diagnostic suggestions (classification). This study will evaluate the effect of a CDSS on the diagnostic certainty and accuracy of OCT assessors.

NCT ID: NCT05550077 Recruiting - Ischemic Stroke Clinical Trials

Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis

OCT-ICAS
Start date: March 15, 2020
Phase:
Study type: Observational [Patient Registry]

To evaluate the clinical significance of optical coherence tomography (OCT) in interventional treatment of intracranial atherosclerotic stenosis (ICAS).

NCT ID: NCT05517889 Completed - Clinical trials for Artificial Intelligence

Repeatability and Stability of Healthy Skin Features on OCT

Start date: September 1, 2022
Phase:
Study type: Observational

A test-retest study on the stability and repeatability of healthy skin features on OCT

NCT ID: NCT05340543 Recruiting - Melanoma Clinical Trials

Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integrated Dermoscopy and Comparison With Histology (DERMOCTAV)

DERMOCTAV
Start date: December 16, 2021
Phase:
Study type: Observational

This project aims to validate ex vivo the use of the OCTAV® prototype integrating the "dermoscope" function before an in vivo application, by comparing images obtained by the OCTAV® prototype integrating the "dermoscope" function with the histological sections of a skin tumor excision corresponding to them exactly, at the same level.