Optic Neuritis Clinical Trial
Official title:
The Correlation Between AQP-4 Ab and the Visual Function of Patients With Demyelinating ON at Onset
To evaluate the optical coherence tomography (OCT), visual field (VF), Visual evoked po-tential(VEP) characteristics between neuromyelitis optica- related optic neuritis (NMOSD-ON) and multiple sclerosis- related ON (MS-ON) in a Chinese cohort.
Status | Recruiting |
Enrollment | 300 |
Est. completion date | December 2016 |
Est. primary completion date | August 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Optic neuritis patients Exclusion Criteria: - The presence of significant refractive errors (3D of spherical equivalent refraction or 2D of astigmatism), intraocular pressure of 21 mmHg or higher, systemic conditions that could affect the visual system, and a history of ocular trauma or concomitant ocular diseases, including a history of media opacification, ocular pathologies affecting the cornea, lens, retinal disease, glaucoma, or laser therapy. All patients in the study groups had an episode of ON more than six months before the study inclusion time point. |
Observational Model: Case Control, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
China | Zhongshan Ophthalmic Center | Guangzhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
Xiujuan Zhao |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | retinal nerve fiber layer thickness | 2013.11-2016.12 | Yes | |
Secondary | visual field | 2013.11-2016.12 | Yes | |
Secondary | visual evoked potential | 2013.11-2016.12 | Yes |
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