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The Correlation Between AQP-4 Ab and the Visual Function of Patients With Demyelinating ON at Onset

Optic Neuritis Clinical Trial

Official title:
The Correlation Between AQP-4 Ab and the Visual Function of Patients With Demyelinating ON at Onset

Clinical Trial Summary

To evaluate the optical coherence tomography (OCT), visual field (VF), Visual evoked po-tential(VEP) characteristics between neuromyelitis optica- related optic neuritis (NMOSD-ON) and multiple sclerosis- related ON (MS-ON) in a Chinese cohort.

Clinical Trial Description

Patients were sub-divided into an AQP4 seropositive group and an AQP4 seronegative group, according to the results of the AQP4-Ab test. All patients with complete medical histories underwent routine neurological examinations, brain MRIs, and ophthalmological examinations, including best corrected visual acuity (BCVA), intraocular pressure, slit lamp and fundus examination, VF and VEP, laboratory testing, including blood routine, HIV HBV HCV Syphilis, mitochondrial DNA sequencing, and a profile of autoantibodies, including antinuclear antibody (ANA), extractable nuclear antigen antibodies (SSA/SSB), rheumatoid factor (RF), anticardiolipin antibodies (ACA), and antithyroglobulin antibody. ;

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02886377
Study type Observational
Source Zhongshan Ophthalmic Center, Sun Yet-san University
Contact Jian Zhang
Phone 020-87334687
Email zoccrc@mail.sysu.edu.cn
Status Recruiting
Phase N/A
Start date November 2013
Completion date December 2016
View Details
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