Measurement of Optic Nerve Sheath Diameter

Optic Nerve Sheath Diameter Clinical Trial

Official title:

Effect of Different Speed of Normal Saline Injection on Optic Nerve Sheath Diameter During Thoracic Epidural Catheterization

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03362255
• Other study ID #: 2017-08-017
• Status: Completed
• Phase: N/A
• Start date: November 13, 2017
• Est. completion date: May 5, 2018

Study information

• Verified date: July 2018
• Source: Keimyung University Dongsan Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia.

This study is designed to compare the optic nerve sheath diameter using 10cc of nomal saline of different speed (3cc/sec vs. 1cc/sec).

Description:

It is known that insufficient intraoperative or postoperative management can lengthen the hospital stay with unwanted complications. Therefore, active and proper management using continuous thoracic epidural catheterization is suggested good option to prevent such potential complication.

According to previous study, injection of different volume of local anesthetics (1.0 ml/kg vs. 1.5 ml/kg) during caudal anesthesia, high volume of local anesthetics resulted in significant increase of intracranial pressure (ICP). Increase of ICP can reduce regional cerebral flow and oxygen saturation causing the safety of patients. In addition, increase of ICP can result in headache, syncope, and transient loss of visual acuity.

Although it is very invasive method, ICP can be measured directly at the brain parenchyme. Among methods to measure the ICP indirectly, measurement of optic nerve sheath diameter using ultrasound is known to reflect the degree of ICP. It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia.

This study is designed to compare the optic nerve sheath diameter using 10cc of nomal saline of different speed (3cc/sec vs. 1cc/sec).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: May 5, 2018
• Est. primary completion date: May 5, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• lung cancer

• liver cancer

• stomach cancer

• pancreas cancer

Exclusion Criteria:

• coagulopathy

• infection

• previous spine fusion at thoracic level

• previous brain surgery

Related Conditions & MeSH terms

• Optic Nerve Sheath Diameter

Intervention

Other:
• thoracic epidural catheterization
thoracic epidural catheterization with different speed of injection

Locations

Country	Name	City	State
Korea, Republic of	Ji Hee Hong	Daegu

Sponsors (1)

Lead Sponsor	Collaborator
Keimyung University Dongsan Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	optic nerve sheath diameter change among 4 time period	optic nerve sheath diameter change among 4 time period using ultrasound	Baseline, 1 minutes, 10 minutes, 30 minutes after the completion of the intervention