Opioid Use Disorder Clinical Trial
Official title:
Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder
The goal of this research study is to examine the endocannabinoid (eCB) function in vivo in individuals with opioid use disorder (OUD) by measuring cannabinoid receptor 1 (CB1R) availability.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | December 15, 2025 |
Est. primary completion date | December 15, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Able to provide informed consent - Male and female 18 years and older - DSM-5 diagnosis of opioid use disorder (for OUD group) - Physically healthy i.e., no clinically unstable medical conditions - Written informed consent and have capacity to consent and comply with study procedures Exclusion Criteria: - Current neuro-psychiatric illness or severe systemic disease (opioid use disorder is permitted in the OUD group). - Presence of ferromagnetic metal in the body or heart pacemaker - Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits - Are claustrophobic |
Country | Name | City | State |
---|---|---|---|
United States | Connecticut Mental Health Center, Clinical Neuroscience Research Unit | New Haven | Connecticut |
Lead Sponsor | Collaborator |
---|---|
Yale University | National Institute on Drug Abuse (NIDA) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | CB1R Availability | To compare cortical CB1R availability in individuals diagnosed with opioid use disorder on chronic methadone maintenance vs. matched healthy controls. | One time within 4 weeks of screening | |
Secondary | Serum Endocannabinoid Levels | To explore group differences in serum endocannabinoid levels in individuals diagnosed with opioid use disorder on chronic methadone maintenance vs. matched healthy controls. | One time within 4 weeks of screening |
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