Opioid-Related Disorders Clinical Trial
Official title:
Biobehavioral Study of Opioid Drug Seeking Behavior: Study 2
The purpose of this study is to determine whether knowledge of post-session hydromorphone (HYD) availability reduces drug seeking behavior in heroin dependent individuals.
Drug dependence is often characterized by severe drug seeking behavior. Learning to
understand, predict, and control this maladaptive choice behavior may lead to improved
prevention and treatment strategies. HYD is a drug that is currently used as a cough
suppressant and to relieve pain. The purpose of this study is to determine the extent to
which opioid drug seeking behavior by heroin dependent individuals can be reduced by
environmental factors, including supplemental opioid drug availability, drug price, and
alternative non-drug reinforcers. Specifically, this study will determine whether knowledge
of post-session HYD availability influences drug seeking behavior in heroin dependent
individuals, who are maintained on buprenorphine during their participation.
Participants in this observational study will take part in multiple trials in which they
have the opportunity to choose either HYD or money. On the first two experimental days,
prior to choice sessions, participants will receive a sample of the drug doses that can be
chosen. During test sessions, participants will have 12 opportunities to choose either drug
or money. Participants will use a computer to earn choices. Respiration rate, oxygen
saturation, heart rate, and blood pressure will be monitored throughout choice trials.
Supplemental HYD will be made available following some choice sessions. Self-report
questionnaires will be completed at different times during the study. Participants will be
maintained on buprenorphine throughout the study, with a minimum 2-week lead before the
experiment, and a fixed 3-week detoxification after study completion.
;
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT03950492 -
Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder
|
N/A | |
| Completed |
NCT00000335 -
Activity Monitoring Assessment of Opiate Withdrawal - 4
|
Phase 2 | |
| Active, not recruiting |
NCT03949764 -
The Kentucky Viral Hepatitis Treatment Study
|
Phase 4 | |
| Enrolling by invitation |
NCT06084221 -
Fatal Overdose Review Teams - Research to Enhance Surveillance Systems
|
N/A | |
| Completed |
NCT02978417 -
Feasibility Study of Extended-release Naltrexone (Vivitrol) in Drug Court Settings
|
Phase 4 | |
| Withdrawn |
NCT03137030 -
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults
|
Phase 1 | |
| Withdrawn |
NCT03137017 -
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
|
Phase 1 | |
| Completed |
NCT02282306 -
Phone Interview to Prevent Recurring Opioid Overdoses
|
N/A | |
| Completed |
NCT00710385 -
Abuse Liability of Suboxone Versus Subutex
|
Phase 3 | |
| Completed |
NCT00142935 -
Effectiveness of Opiate Replacement Therapy Administered Prior to Release From a Correctional Facility - 1
|
N/A | |
| Completed |
NCT00218309 -
Effects of Pre-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals
|
Phase 2 | |
| Completed |
NCT00067184 -
Fetal Neurobehavioral Development in Methadone Maintained Pregnancies
|
||
| Terminated |
NCT00000243 -
Effects of Buprenorphine/Naloxone in Treating Opioid Dependent Individuals Who Are Maintained on Methadone
|
N/A | |
| Completed |
NCT00000264 -
Subjective/Psychomotor/ Effects of Combined Alcohol & Nitrous Oxide - 16
|
N/A | |
| Completed |
NCT00000257 -
Effects of Alcohol History on Effects of Nitrous Oxide - 9
|
N/A | |
| Completed |
NCT00000306 -
Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3
|
Phase 2 | |
| Completed |
NCT00000279 -
Novel Medications for Opiate Detoxification - 4
|
Phase 2 | |
| Completed |
NCT00000249 -
Effects of Subanesthetic Concentrations of Nitrous Oxide - 1
|
Phase 2 | |
| Recruiting |
NCT04933084 -
Pre-operative Education Modalities to Decrease Opioid Use
|
N/A | |
| Recruiting |
NCT03610672 -
Mobile Intervention for Young Opioid Users
|
N/A |