Opioid-Related Disorders Clinical Trial
Official title:
Dose Reduction Strategies in Oral Opioid Dependence Subsequent to Pain Management: An Exploratory Study
Opioids used to treat chronic pain have a high abuse potential. The purpose of this study is to determine the effectiveness of buprenorphine in treating opioid dependent individuals who abuse opioids that are prescribed for chronic pain.
Many individuals who take opioids for chronic pain abuse the opioid medication.
Buprenorphine is an opioid partial agonist that may be effective in treating individuals who
abuse opiate pain medication. The purpose of this study is to compare two buprenorphine
dosing regimens in order to determine which regimen is more effective in reducing opiate
pain medication use and facilitating successful opioid detoxification.
This study will last 27 weeks. Participants will receive a maintenance dose of 8 mg of
buprenorphine for 6 weeks, followed by a dose reduction in 2 mg increments over the course
of the following 20 weeks. All participants will attend weekly clinical management sessions
for the duration of the study.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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