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Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery

Opioid Consumption Clinical Trial

Official title:
Investigating the Effect of a Perioperative Analgesia Protocol on Postoperative Opioid Usage and Pain Control in Patients Undergoing Major Head and Neck Cancer Surgery Requiring Microvascular Free Flap Reconstruction

Clinical Trial Summary

The purpose of this study is to determine how a non-opioid pain control regimen, administered before and during surgery, will affect postoperative pain control and total opioid consumption in head and neck cancer participants undergoing cancer surgery with free flap reconstruction.

Clinical Trial Description

This study will help the study team determine how the experimental, non-opioid pain control regimen affects opioid-related side effects, participant satisfaction with pain management, PACU length of stay, hospital length of stay, chronic pain level, and chronic pain-related disability in participants, and to determine the safety and tolerability of the non-opioid pain control regimen in head and neck cancer patients undergoing cancer surgery with free flap reconstruction. Ketamine, Lidocaine, Acetaminophen, Gabapentin, and Celecoxib are FDA-approved drugs that have been approved for use individually, and have been used in combination for perioperative pain control. However, the use of these five drugs together in head and neck cancer patients undergoing free flap reconstruction has not been studied, which is why this study is experimental. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04176419
Study type Interventional
Source Case Comprehensive Cancer Center
Contact
Status Active, not recruiting
Phase Phase 3
Start date January 17, 2020
Completion date October 31, 2024
View Details
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