Open Angle Glaucoma Clinical Trial
Official title:
Correlation Between Retinal Metabolism and the Observation of a Visible Retinal Spontaneous Venous Pulse
Retinal ischemia is thought to play an important role in the pathogenesis of glaucoma.
Recent findings have confirmed that there is a direct correlation between the levels of
venous oxygen saturation and the degree of the glaucomatous disease, presumably due to a
decrease in retinal cell metabolism.
However, glaucoma patients have been suggested to have a different pattern in retinal venous
circulation. For instance, the observation of a visible pulsating central retinal vein is a
phenomenon that can be seen in up to 98% of the healthy individuals but is identifiable in
less than 50% of glaucoma patients. While the nature of these venous changes are not year
clear, the lack of a visible pulsating flow could suggest an increased intraluminal venous
pressure due to some obstruction from both ocular or extraocular structures. This
undetermined increase in venous pulse pressure could then significantly decrease perfusion
pressures and therefore further decrease oxygen supply to the retinal tissues.
The investigators will therefore try to determine if there is a significant difference
between the oxygen saturation of the retinal vessels in both glaucoma patients with and
without a visible pulsating central vein
1. Visual field examen will be performed.
2. Structural examination of the optic disc (confocal microscopy) will be performed.
3. Spontaneous venous pulsation will be recorded after a one minute fundoscopy
observation.
4. Oximetry reading in the non-contact retinal oximetry of the first 3 order retinal
vessels
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