Open-angle Glaucoma Clinical Trial
Official title:
Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Primary Open-angle and Normal Tension Glaucoma Patients
Color Doppler Imaging (CDI) has been providing information about ocular blood flow over the
past decades. This non-invasive procedure based on ultrasound technique has identified
increased resistance and decreased systolic blood velocities to exist in the ophthalmic
arteries of glaucoma patients. However, existing data has provided very little information
regarding the analysis of the Doppler waveform in itself and to whether variables such as
early systolic acceleration or systolic/diastolic velocity ratios are of any significance in
glaucoma disease. In other medical specialties using CDI technology, such as nephrology or
cardiology for instance, this analysis has been part of the normal routine. This information
has been used in screening patients for disturbed circulation such as arterial stenosis or
providing information regarding prognosis of renal and hepatic transplants have been used
for decades now.
What is the normal characteristics of the waveform Doppler analysis? To answer this, the
investigators will create a normative database using healthy controls.
Are there signs of altered stiffness or compliance in the ophthalmic arteries of glaucoma
patients? To answer this, the analysis of early acceleration acceleration and detection of
an early peak systolic will be done on the Doppler curves of glaucoma patients and compared
to the healthy normative database.
Are there any difference between the two types of glaucoma [primary open-angle glaucoma
(POAG) and normal-tension glaucoma (NTG)]? The investigators will compare the variables of
the ophthalmic artery waveform in these two groups.
Do any of these Doppler waveform variables have any clinical significance? To answer this,
the investigators will search for the existence of any correlation between the waveform data
and both functional (visual field testing) and structural (Confocal scanning laser
ophthalmoscopy - CSLO) variables of the glaucoma groups.
1. Color Doppler imaging of the ophthalmic artery will be performed 2. Visual field testing will be done 2. CSLO will be done ;
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