Open Angle Glaucoma Clinical Trial
Official title:
Comprative Study of the Safety and Effectiveness Between Oculusgen (Ologen) Collagen Matrix Implant and Mitomycin-C in Glaucoma Filtering Surgery
To compare the safety and effectiveness between ologen collagen matrix and mitomycin-C (MMC)
in glaucoma surgery.
The ologen collagen matrix implantation procedure is same as traditional trabeculectomy
except implant the ologen collagen matrix on the top of sclera flap after one loose stich
the sclera flap. The MMC application is as the standard.
Ologen collagen matrix is implanted on the top of sclera flap after the loose stich sclera
flap is done for the filtering surgery. The concept of ologen collagen matrix is to creat
the subconjunctiva bleb and modulate the wound healing for the surgery. By implanting ologen
collagen matrix in the place, subconjuctival and trabdoor scars might be prevented. This is
because the ologen collagen matrix is a 3-D scaffold porous structure that can guide
fibroblast to grow randomly, instead of linear alignment. This can reduce the scar
formation.
Doctors apply MMC for the glaucoma surgery is also trying to inhibite the scar formation.
But MMC has been long time used and glaucoma specialists have not found anything to replace
it.
Ologen collagen matrix concept is not INHIBITION, it is guiding and creating a physiological
tissue. The successful of ologen collagen matrix may be on par with MMC but the safety and
side effects will be much less.
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