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NCT03793088 Clinical Trial

A Patient-Centric Platform Trial for Precision Oncology

Oncology Clinical Trial

— XCELSIOR  

Official title:
xCures/CancerCommons Enhanced Learning Treatment Selection and Analysis With Outcomes Research (XCELSIOR) Study: A Patient-Centric Platform Trial for Precision Oncology

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03793088
Other study ID # XC3-GCTA-2018
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date February 7, 2019
Est. completion date January 2026

Study information
Verified date January 2023
Source xCures
Contact Bryan J Federowicz
Phone 707-641-4475
Email bfederowicz@xcures.com
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

XCELSIOR is a non-interventional data registry. Information about treatments, treatment decisions and rationale, and patient outcomes including safety and effectiveness of anti-cancer therapy and associated supportive care will be collected for analysis.

Description:

XCELSIOR is patient-centric study for the registration of cancer patients, operations of a virtual tumor board, insight capture in clinical decision making, and collection of longitudinal, observational data in a cancer registry. Patient intake into XCELSIOR will occur through the Cancer Commons Web portal. This includes consent to participate in the data registry, including the collection and review of medical information by a Virtual Tumor Board, generation of patient-specific treatment options with supporting rationale, access to treatment access support services, and inclusion into a registry study that includes safety and efficacy outcomes tracking. Patients will be treated and tracked in their original treatment setting and the data generated will form part of a systematic framework combining expert judgment with artificial intelligence to maximize information gain and improve treatment option set development for individual cancer patients.

Recruitment information / eligibility
Status Recruiting
Enrollment 10000
Est. completion date January 2026
Est. primary completion date January 2024
Accepts healthy volunteers No
Gender All
Age group 0 Years and older
Eligibility Inclusion Criteria: - Both male and female patients with known or suspected recalcitrant or advanced cancer are eligible to enroll through the Cancer Commons Website - Patients with any performance status, comorbidity or disease severity are eligible - Patients or their legally-authorized representative must be willing and able to provide written, informed consent (and assent, if applicable) Exclusion Criteria: - Patients must be a resident of or receiving care within the United States or US territories.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Cancer Commons Los Altos California

Sponsors (4)
Lead Sponsor Collaborator
xCures Cancer Commons, Musella Foundation for Brain Tumor Research and Information, Inc., Pediatric Oncology Experimental Therapeutics Investigators Consortium

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Progression Free Survival (PFS) 5 Years
Primary Overall Survival (OS) 5 years
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