Creatine and Ubiquinol for Sperm Quality

Oligospermia Clinical Trial

— CRESPAQ10  

Official title:

The Effects of 8-week Creatine Supplementation With and Without Ubiquinol on Sperm Quality Biomarkers in Normospermic and Oligospermic Men

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06202469
• Other study ID #: CR-24-AK15
• Status: Recruiting
• Phase: N/A
• Start date: December 15, 2023
• Est. completion date: June 30, 2024

Study information

• Verified date: January 2024
• Source: University of Novi Sad, Faculty of Sport and Physical Education
• Contact: Sergej Ostojic, MD, PhD
• Phone: +38121450188
• Email: sergej.ostojci[@]chess.edu.rs
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men. It aims to determine potential enhancements in sperm health to provide insights into male fertility and reproductive health improvement strategies.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 18
• Est. completion date: June 30, 2024
• Est. primary completion date: May 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Age 18 - 35 years

• Sperm quality test available (at least half will have low sperm quality)

• Informed consent

• Healthy BMI (18.5 - 24.9 kg/m2)

Exclusion Criteria:

• Major chronic disease and acute injuries

• History of dietary supplement use during the past 28 days

• No consent to randomization

• Participation in other studies

Related Conditions & MeSH terms

• Oligospermia
• Sperm Count, Low

Intervention

Dietary Supplement:
• Supplement 1
Creatine monohydrate (5 g/day)
• Supplement 2
Creatine monohydrate (5 g/day) plus ubiquinol (200 mg/day)
• Placebo
Placebo (inulin)

Locations

Country	Name	City	State
Serbia	FSPE Applied Bioenergetics Lab	Novi Sad	Vojvodina

Sponsors (1)

Lead Sponsor	Collaborator
University of Novi Sad, Faculty of Sport and Physical Education

Country where clinical trial is conducted

Serbia, 

References & Publications (1)

Ostojic SM, Stea TH, Engeset D. Creatine as a Promising Component of Paternal Preconception Diet. Nutrients. 2022 Jan 28;14(3):586. doi: 10.3390/nu14030586. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sperm concentration	Number of sperm per milliliter of semen	Change from baseline sperm concentration at 8 weeks
Secondary	Total antioxidant capacity	Level of total antioxidant capacity in semen	Change from baseline total antioxidant capacity at 8 weeks
Secondary	Creatine kinase	Level of creatine kinase in semen	Change from baseline creatine kinase at 8 weeks
Secondary	Creatine	Level of creatine in semen	Change from baseline creatine at 8 weeks
Secondary	The World Health Organisation-Five Well-Being Index (WHO-5)	The World Health Organisation-Five Well-Being Index (WHO-5) is a short self-reported measure of current mental wellbeing.The raw scores are transformed to a score from 0 to 100, with lower scores indicating worse well-being.	Change from baseline WHO-5 at 8 weeks