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Oligohydramnios clinical trials

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NCT ID: NCT05559957 Completed - Clinical trials for Oligohydramnios, Delivered

Isolated Oligohydramnios Less Favorable Delivery and Neonatal Outcomes

Start date: January 1, 2020
Phase:
Study type: Observational [Patient Registry]

Oligohydramnios happens in 1-5% of term pregnancies. The clinical significance of isolated oligohydramnios been a matter of debate. We aimed in this study to investigate the impact of isolated oligohydramnios on the mode of delivery and risk of adverse perinatal outcome.

NCT ID: NCT05332015 Completed - Oligohydramnios Clinical Trials

The Effect of Oral Hypotonic Hydration in Isolated Oligohydramnios

Start date: April 28, 2022
Phase: N/A
Study type: Interventional

OBJECTIVE: The primary objective of our study is to compare the effects of routine hydration with additional 2 liters of normal water versus orally 2 liters of distilled water on the amount of amniotic fluid. HYPOTHESIS: İsolated oligohydramnios, secondary to depleted maternal intravascular volume, can be reversed better with orally hypotonic water.

NCT ID: NCT05059093 Completed - Clinical trials for Fetal Growth Restriction

Developing and Testing AI Models for Fetal Biometry and Amniotic Volume Assessment in Fetal Ultrasound Scans.

Start date: October 25, 2021
Phase:
Study type: Observational

Routine fetal ultrasound scan during the second trimester of the pregnancy is a low-cost, noninvasive screening modality that has been proven to lower fetal mortality by up to 20%. One of the critical elements of this exam is the measurement of fetal biometric parameters, which are the head circumference (HC), biparietal diameter (BPD), abdominal circumference (AC), and femur length (FL) measured on biometry standard planes. Those standard planes are taken according to quality standards first described by Salomon et al. and used as the guidelines of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG). The biometric parameters extracted from them are essential to diagnose fetal growth restriction (FGR), the world's first cause of perinatal fetal mortality. Such measurements and image quality assessment are time-consuming tasks that are prone to inter and intraobserver variability depending on the level of skill of the sonographer or the physician performing the exam. Amniotic fluid (AF) volume assessment is also an essential step in routine screening scans allowing the diagnosis of oligo or hydramnios, both associated with increased fetal mortality rates. The AF is measured by two main "semi-quantitative" techniques: Amniotic Fluid Index (AFI) and the single deepest pocket (SDP). The latter is more specific as it lowers the overdiagnosis of oligo-amnios without any impact on mortality or morbidity and is easier to perform for the sonographer (only one measurement versus four in the case of the AFI technique). However, AF assessment remains a time-consuming and poorly reproducible task. Attempts to automate such biometric measurements and AF volume assessment have been made using Artificial Intelligence (AI) and deep learning (DL) tools. Studies showed excellent results "in silico," reaching up to 98 %, 95%, 93 % dice score coefficients for HC, AC, and FL measurements and 89 % DSC for AFI measurements. However, they were all conducted retrospectively without validation on prospectively acquired images. Reviews and experts have stressed the need for quality peer-reviewed prospective studies to assess AI tools' performance with real-world data. Their performance is expected to be worse and to reflect better their use in the clinical workflow. This study aims to develop DL models to automate HC, BPD, AC, and FL measurements and AF volume assessment from retrospectively acquired data and test their performances to those of clinicians and experts on prospective real-world fetal US scans.

NCT ID: NCT03935607 Completed - Oligohydramnios Clinical Trials

The Added Contribution of Transvaginal Sonographic Evaluation of Amniotic Fluid Index

Start date: July 1, 2019
Phase:
Study type: Observational

The current study is based on the use of transvaginal sonography in the evaluation of oligohydramnios. Patients will be recruited after amniotic fluid index evaluation according to transabdominal sonography. After obtaining informed consent, transvaginal sonography will be used to evaluate and measure a possible amniotic fluid pocket that may precede the fetal presenting part.

NCT ID: NCT03703037 Completed - Ultrasound Clinical Trials

Uterine, Fetal Cerebral Doppler and Oligohydramnios to Predict Abnormal Heart Rate Tracings in Postterm Pregnancies

Start date: January 1, 2016
Phase:
Study type: Observational

Objective: To estimate the value of uterine, fetal cerebral Doppler and oligohydramnios to predict abnormal fetal heart rate tracings in pregnancies at or beyond 41 weeks

NCT ID: NCT02712125 Completed - Clinical trials for Isolated (Idiopathic) Oligohydramnios

Nitric Oxide Donors for Treatment of Isolated Oligohydramnios

Start date: August 2013
Phase: Phase 2/Phase 3
Study type: Interventional

Objective: To assess the influence of maternal isosorbide mononitrate (IMN) vaginal supplementation in improving liquor volume in women with isolated oligohydramnios. Study Design: Prospective randomized interventional study. Materials and Methods: 100 women with singleton pregnancy about 28-36 weeks, with isolated oligohydramnios [amniotic fluid index (AFI) < 5] were enrolled in the study. Before the proposed intervention, the antenatal risk factors were studied. Patients received 20 mg isosorbide mononitrate (IMN) vaginally. Patient were followed after 24 hours then weekly. The treatment was continued till the liquor improved significantly or until delivery. Outcome measures; mean increase in liquor, intervention delivery interval, and neonatal outcome were studied.

NCT ID: NCT02581774 Completed - Oligohydramnios Clinical Trials

Active Induction of Labor in Pregnancies Complicated With Oligohydramnios at Term

Start date: January 2013
Phase: Phase 4
Study type: Observational

The purpose of this study is to evaluate the risk of cesarean delivery in pregnancies complicated with isolated oligohydramnios managed by induction of labor. This prospective case-control study was conducted in Hamıdıye Sisli Etfal Teaching and Research Hospital between January 2013 and June 2014. 159 women with isolated oligohydramnios and 165 women with postdate pregnancies who met the inclusion criteria underwent induction of labor with dinoprostone or oxytocin. The rate and the indications of C/S deliveries were compared between two groups.

NCT ID: NCT01990690 Completed - Oilgohydramnios Clinical Trials

Role of Antioxidants in Unexplained Oligohydramnios,A Randomized Trial

ao&uoh
Start date: January 2015
Phase: Phase 4
Study type: Interventional

To predict the effect of antioxidants in cases of oligohydramnios

NCT ID: NCT01140971 Completed - Oligohydramnios Clinical Trials

Foley Catheter Versus Vaginal Misoprostol for Cervical Ripening and Induction of Labor

Start date: January 2006
Phase: N/A
Study type: Interventional

PURPOSE: The purpose of this study is to determine the effectiveness of balloon dilatation (Foley) with vaginal misoprostol for cervical ripening and induction of labor. METHOD: a randomized clinical assay has been performed with 160 women with indication of induction of labor, randomly divided in two groups, 80 for Foley catheter and 80 for misoprostol.