Clinical Trials Logo

Clinical Trial Summary

This cohort study aims to investigate the long-standing chemosensory disorders and oral manifestation after recovery of the COVID-19 illness. A correlation between the long-standing symptoms and the COVID-19 severity grade will be very important to understand and clarify the aetiology of these symptoms.


Clinical Trial Description

This prospective cohort study aims to investigate the long-standing chemosensory disorders and oral manifestation after recovery of the COVID-19 illness. A correlation between the long-standing symptoms and the COVID-19 severity grade will be very important to understand and clarify the aetiology of these symptoms. Study objectives: 1. To describe the frequency and severity of oral signs and chemosensory disorders that persist after the recovery of COVID-19 and to examine whether "taste disorders" can be discriminated into an- or hypogeusia and an- or hyposmia. 2. To report any correlation between the severity grade of COVID-19 and the resulting standing symptoms. 3. To describe the oral microbiome after infection with COVID-19 and to describe possible changes in comparison to normal healthy individuals. Clinical and -if indicated- radiological examination to assess the long-term oral and chemosensory impairment and complaints of COVID-19 patients after their recovery shall be performed in an interdisciplinary setting of Maxillofacial Surgery, ENT and Medical Microbiology. The study subjects will be divided into three groups according to the severity grade of illness: non-hospitalized, hospitalized, and intensive care patients. All adult COVID-19 recovery patients (exceeding the age of 18) will be included in the study. The time between illness and study recruitment shall be at least 3 months. Exclusion criteria are psychiatric or neurological diseases, previous trauma, surgery or radiotherapy in the oral or nasal cavities, pre-existing taste or smell dysfunctions or chronic rhinosinusitis. The study variables include age, sex, co-morbidities, possible causes of exclusion from the study. The oral health assessment will be performed by examination of: periodontal status, assessment of oral lesions, a radiological examination by using panoramic x-ray if clinically indicated, photo documentation, objective evaluation of the olfactory and gustatory functions with psychophysical tests. The gustatory and olfactory function will be tested by using the combined Burghart Screening 12 test containing smelling sticks and taste strips (Fa. MediSense, Groningen, Netherlands). Evaluation of taste and smell is performed by offering the sticks/strips and demand a forced multiple choice. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04791436
Study type Observational
Source University of Giessen
Contact Sameh Attia, MSc
Phone 00496419946110
Email Sameh.Attia@dentist.med.uni-giessen.de
Status Recruiting
Phase
Start date May 1, 2021
Completion date January 28, 2023

See also
  Status Clinical Trial Phase
Completed NCT04617444 - The ESTxENDS Trial- Substudy on Effects of Using Electronic Nicotine Delivery Systems (ENDS) on Olfactory Function N/A
Completed NCT02985515 - Steroid Nasal Irrigation for Flavor Evaluation and Detection Study N/A
Recruiting NCT06066307 - Olfactory Performance in Culinary Arts Students Phase 4
Completed NCT05445921 - Stellate Ganglion Block for COVID-19-Induced Olfactory Dysfunction Phase 1/Phase 2
Recruiting NCT05855369 - Smell Training and Trigeminal Nerve Stimulation for COVID-related Smell Loss Phase 2/Phase 3
Recruiting NCT03574701 - Intranasal Retinoic Acid Treatment for Patients With OlfactoryLOSS: A RANDOMIZED CONTROLLED TRIAL N/A
Enrolling by invitation NCT04764981 - Olfactory Training for Olfactory Dysfunction After Coronavirus Disease - 19 (COVID-19) N/A
Completed NCT03990766 - Smell Changes & Efficacy of Nasal Theophylline Phase 2
Withdrawn NCT05542095 - Simvastatin Nasal Rinses for the Treatment of COVID-19 Mediated Dysomsia Phase 1
Enrolling by invitation NCT05038475 - Clinical and Immunological Responses After SARS-CoV-2 Infection Causing COVID-19
Completed NCT01332825 - cAMP (Cyclic Adenosine Monophosphate) Levels in the Nose N/A
Completed NCT04789499 - Smell in Covid-19 and Efficacy of Nasal Theophylline Phase 2
Active, not recruiting NCT04761458 - Correlation of Preoperative Global Olfactory Function With Frailty, Perioperative Neurocognitive Disorders and Mortality N/A
Completed NCT04406584 - Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction N/A
Completed NCT03611673 - At-Home Olfactory Training N/A
Completed NCT04700891 - Correlation of Preoperative Olfactory Identification Function With Frailty and Postoperative Complications and Mortality N/A
Recruiting NCT04466982 - Assessment of Olfactory Dysfunction in SARS CoV-2 (COVID-19) Infection
Recruiting NCT04869436 - Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis Phase 4
Recruiting NCT05448898 - The Efficacy of Traditional Chinese Medicine in Olfactory Dysfunction N/A
Completed NCT04235153 - CAncer, NUtrition and Taste - Validation of the CANUT-QVA Questionnaire on Eating Habits in Cancer Patients