Older Adults Clinical Trial
Official title:
Effects of Remote Limb Ischemic Conditioning on Motor Learning in Middle-aged and Older Adults
The purpose of this research is to determine if the beneficial effects of remote limb ischemic conditioning on learning seen in young adults are found in middle-aged and older adults.
Ischemic conditioning is an endogenous phenomenon in which exposing a target organ or tissue
to one or more brief episodes of ischemia results in protection of that organ against
subsequent ischemia. The effects of ischemic conditioning are not confined within an organ
but can be can be transferred from one organ to another, a technique called remote ischemic
conditioning. A clinically feasible method for this is remote limb ischemic conditioning
(RLIC), where episodes of ischemia and perfusion are induced with a blood pressure cuff
placed on the arm.
The overall goal of this line of work is to use ischemic conditioning to enhance learning and
outcomes in persons with neurologic injuries. Two previous studies have shown that remote
limb ischemic conditioning (RLIC) can enhance learning a motor task in healthy young adults.
The next step is to determine which individuals would receive maximum benefit from RLIC
before applying these findings to clinical rehabilitation populations such as stroke.
Numerous factors, such as age, body mass index (BMI), sex, and cardiovascular comorbidities
may influence the response. The current study determines if RLIC can enhance learning in
middle-aged and older adults with their burden of co-morbidities.
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