Step-reduction in Older Men and Women

Older Adults Clinical Trial

— CDA-SR  

Official title:

The Influence of Acute Physical Inactivity on Metabolic Function in Older Men and Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03039556
• Other study ID #: 0574
• Status: Completed
• Phase: N/A
• First received: January 13, 2017
• Last updated: January 31, 2017
• Start date: September 2015
• Est. completion date: May 2016

Study information

• Verified date: January 2017
• Source: McMaster University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study investigates the effects of two weeks of reduced daily ambulation and a subsequent return to normal physical activity on metabolic health of older adults.

Description:

Aging results in a progressive loss of muscle mass that is accelerated by periods of muscular disuse, common for older adults during hospitalization or convalescence from illness. Transient physical inactivity has been shown to cause muscular atrophy and impairments in insulin sensitivity in both younger and older adults. However, the recovery capacity of older adults after such physical inactivity remains unknown. This study aims to determine the impact of two weeks of daily step reduction to ≤1000 steps per day, an experimental model mimicking short-term physical inactivity, on glycemic control in older adults and further investigate whether older adults are able to recover from the consequences of this inactivity simply by returning to their habitual activity for 14 days.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: May 2016
• Est. primary completion date: May 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years to 80 Years

Eligibility

Inclusion Criteria:

• Non-smoker

Exclusion Criteria:

• Use of assistive walking devices

• Chronic use of analgesic or anti-inflammatory drugs

• History of neuromuscular problems or muscle and/or bone wasting disease

• Acute or chronic illness including cardiac, pulmonary, liver or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders

• Daily use of statins, particularly simvastatin and atorvastatin

• Use of medications known to affect protein metabolism

• Normally complete fewer than 3000 steps per day

Related Conditions & MeSH terms

• Older Adults
• Reduced Physical Activity

Intervention

Behavioral:
• Normal Daily Steps
Complete normal daily ambulation for one week
• Step-Reduction
Reduce daily ambulation to fewer than 1000 steps per day for two weeks
• Return to Normal Daily Steps
Increase daily ambulation to 100% of normal daily step-count for two weeks

Locations

Country	Name	City	State
Canada	Exercise Metabolism Research Laboratory, McMaster Univeristy	Hamilton	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
McMaster University	Canadian Diabetes Association

Country where clinical trial is conducted

Canada, 

References & Publications (2)

Breen L, Stokes KA, Churchward-Venne TA, Moore DR, Baker SK, Smith K, Atherton PJ, Phillips SM. Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab. 2013 Jun;98(6):2604-12. doi: 10.1210/jc.2013-1502. — View Citation

Devries MC, Breen L, Von Allmen M, MacDonald MJ, Moore DR, Offord EA, Horcajada MN, Breuillé D, Phillips SM. Low-load resistance training during step-reduction attenuates declines in muscle mass and strength and enhances anabolic sensitivity in older men. Physiol Rep. 2015 Aug;3(8). pii: e12493. doi: 10.14814/phy2.12493. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Insulin Sensitivity	Assessed via Matsuda ISI	Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Secondary	Change in lean tissue mass	Assessed via Dual Energy X-Ray Absorptiometry	Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Secondary	Change in Peak Isometric Maximal Voluntary Leg Extension Strength	Assessed via muscle dynamometry	Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Secondary	Change in Muscle Protein Synthesis	Obtained via vastus lateralis muscle biopsy	Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)