Regional Blood Flow Clinical Trial
Official title:
Role of endothelin-and Nitric Oxide-system in the Regulation of Optic Nerve Head Blood Flow During Changes in Ocular Perfusion Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in
perfusion pressure. The existence of an effective autoregulation in the optic nerve
circulation has been shown in animals and humans. The exact mechanism behind this
autoregulation is still unknown. The motive for the investigation of optic nerve head (ONH)
blood flow autoregulation is to enhance the understanding of pathologic eye conditions
associated with ocular vascular disorders. To clarify the regulatory mechanisms of ONH
microcirculation is of critical importance to understand the pathophysiology of glaucoma
because there is evidence that glaucoma is associated with optic nerve head ischemia. Several
studies indicate that a disturbed autoregulation might contribute to glaucomatous optic
neuropathy. Previous findings suggest endothelial dysfunction in glaucomatous optic
neuropathy, in particular alterations in endothelin- and nitric oxide- system, which both
play an important role in local regulation of vascular tone.
In the present study, changes in ocular perfusion pressure will be performed during
administration of drugs, which may potentially alter the pressure-flow relationship. These
drugs include endothelin-1 and the nitric oxide synthase inhibitor NG-monomethyl-L-arginine
(L-NMMA).
n/a
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