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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05843604
Other study ID # 2022-A00463-40
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date July 3, 2023
Est. completion date September 2025

Study information

Verified date August 2023
Source Centre Hospitalier Henri Laborit
Contact Damien Doolub, MD
Phone +33 (0)5 16 61 18
Email damien.doolub@ch-poitiers.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.


Recruitment information / eligibility

Status Recruiting
Enrollment 100
Est. completion date September 2025
Est. primary completion date May 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria: - Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions) - Understand and accept the constraints of the study - Be a beneficiary or affiliated to a Health Insurance scheme Exclusion Criteria: - Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998) - Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998) - Have a serious intercurrent pathology - Being a pregnant woman - Being a woman of childbearing age without effective contraception. - Being hospitalized under duress or on an outpatient basis in a care program - Being under judicial protection (reinforced curatorship, guardianship)

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Functional MRI
Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

Locations

Country Name City State
France Centre Hospitalier Henri Laborit Poitiers

Sponsors (1)

Lead Sponsor Collaborator
Centre Hospitalier Henri Laborit

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Cerebral activity modification during N-back task Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls Day 1
Primary Cerebral activity modification during Stroop task Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls Day 1
Primary Cerebral activity modification during switching task (Monsell et Mizon task ) Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls Day 1
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