OCD Clinical Trial
— 3TOCOfficial title:
Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care
NCT number | NCT05843604 |
Other study ID # | 2022-A00463-40 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | July 3, 2023 |
Est. completion date | September 2025 |
This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | September 2025 |
Est. primary completion date | May 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions) - Understand and accept the constraints of the study - Be a beneficiary or affiliated to a Health Insurance scheme Exclusion Criteria: - Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998) - Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998) - Have a serious intercurrent pathology - Being a pregnant woman - Being a woman of childbearing age without effective contraception. - Being hospitalized under duress or on an outpatient basis in a care program - Being under judicial protection (reinforced curatorship, guardianship) |
Country | Name | City | State |
---|---|---|---|
France | Centre Hospitalier Henri Laborit | Poitiers |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Henri Laborit |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cerebral activity modification during N-back task | Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls | Day 1 | |
Primary | Cerebral activity modification during Stroop task | Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls | Day 1 | |
Primary | Cerebral activity modification during switching task (Monsell et Mizon task ) | Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls | Day 1 |
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