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How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD

OCD Clinical Trial

Official title:
Harnessing Hormonal Variation to Probe Neural Mechanisms and Optimize CBT Outcomes for OCD

Clinical Trial Summary

Studies show that hormones affect the brain's fear extinction network, which is relevant for therapy involving exposure and response prevention (EX/RP), a first-line treatment for obsessive compulsive disorder (OCD). This study will examine the effect of delivering EX/RP to women during different phases in their menstrual cycle to determine the effects of hormones on the fear extinction network and on their OCD symptoms.

Clinical Trial Description

This study involves neuroimaging and a brief EX/RP protocol. The investigators will recruit both male and female participants. All participants will complete neuroimaging, hormonal assays and symptom ratings before and after a brief course of EX/RP. Female participants will be randomized to complete brief EX/RP during distinct phases of their menstrual cycles. This design will allow the investigators to study the effects of hormonal variation during the menstrual cycle and sex on the fear extinction network and on EX/RP outcome. The long-term goal is to optimize EX/RP for individuals suffering from OCD. Men will also be recruited for this study to further explore biological sex differences. The results will elucidate treatment mechanisms and could lead to personalized treatment recommendations for women with OCD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05359562
Study type Interventional
Source University of Pennsylvania
Contact Bryanna Mackey
Phone 2157463344
Email Bryanna.Mackey@Pennmedicine.upenn.edu
Status Recruiting
Phase N/A
Start date June 15, 2022
Completion date June 2026
View Details
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