Early Incidence of Occupational Asthma Among Bakers, Pastry-makers and Hairdressers

Occupational Asthma Clinical Trial

— ABCD  

Official title:

Evolution of the Incidence of Occupational Asthma at the Beginning of the Activity of Young Bakers, Pastry-makers and Hairdressers, and Exploration of Its Risk Factors

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01096537
• Other study ID #: 2008-A00622-53
• Status: Completed
• Phase: N/A
• First received: March 10, 2010
• Last updated: July 4, 2016
• Start date: December 2008
• Est. completion date: June 2010

Study information

• Verified date: March 2016
• Source: Central Hospital, Nancy, France
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: French Data Protection Authority
• Study type: Observational

Clinical Trial Summary

Background: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. Because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (OA) during the first years after inception of exposure. This study focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of OA in these "at risk" occupations according to exposure duration, and to identify risk factors of OA.

Methods: This study is a longitudinal retrospective study with a nested case-control to identify risk factors of OA. The assessment of incidence evolution is made by exploring a series of promotions (or retrospective cohorts) with increasing duration since at work. The study population is composed of subjects who graduated between 2001 and 2006 in sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure.

This study is a descriptive, monocentric, longitudinal and retrospective study with cross-sectional measurements.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 866
• Est. completion date: June 2010
• Est. primary completion date: January 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• for the exposed group: to be graduated between 2001 and 2006 from nine vocational schools in Lorraine, North-Eastern France

• for the "non-exposed" group: to be graduated in 2001 in the sale or the food sectors (butcher, pork butcher, caterer, cook job,…) from the same vocational schools

Exclusion Criteria:

• asthma diagnosed before apprenticeship

• for the "non-exposed" group: to have worked previously or later in a sector at risk with OA

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Asthma
• Asthma, Occupational
• Occupational Asthma

Locations

Country	Name	City	State
France	CHU Nancy	Nancy

Sponsors (3)

Lead Sponsor	Collaborator
Central Hospital, Nancy, France	Institut National de la Santé Et de la Recherche Médicale, France, University of Nancy

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The early incidence of OA among young workers according to their sector of activity and exposure duration.		3-6 months after tle last inclusion	No
Secondary	The identification of risk factors of OA.		3-6 months after the last inclusion	No