Comparative Study of Pathophysiological Mechanisms and Bronchial Response in Occupational Asthma to Wheat Flour and Quaternary Ammonium Compounds During Standardized Bronchial Provocation Tests

Occupational Asthma Clinical Trial

Official title: Comparative Study of Pathophysiological Mechanisms and Bronchial Response in Occupational Asthma to Wheat Flour and Quaternary Ammonium Compounds During Standardized Bronchial Provocation Tests

Status Terminated

Clinical Trial Summary

Occupational asthma (OA) caused by high molecular weight (HMW) substances have been shown to induce predominantly an eosinophilic inflammation. In contrast, OA caused by low molecular weight (LMW) substances results in a neutrophilic inflammation. In addition, data regarding phenotype of lymphocytes in OA caused by HMW and LMW substances are scarce. The use of a new equipment will allow the realization of specific standardized bronchial challenges (BC) to occupational agents. Thus, we propose to study in more detail the cellular mechanisms involved during BC to HMW and LMW occupational agents in a double-blind placebo controlled study.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Asthma
• Asthma, Occupational
• Occupational Asthma

• NCT number: NCT01783873
• Study type: Interventional
• Source: University Hospital, Strasbourg, France
• Status: Terminated
• Phase: N/A
• Start date: September 2012
• Completion date: December 12, 2019