Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma

Chronic Periodontitis Clinical Trial

Official title: Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma

Status Completed

Clinical Trial Summary

Present study suggests that excessive occlusal forces did not cause a significant change in hypoxia and vascular markers, however a slight alteration in subgingival microbiota was observed.

Clinical Trial Description

Occlusal trauma is defined as tissue destruction and/or injury resulting in tissue changes in the periodontium as a consequence of excessive occlusal forces or hyper-occlusion. Previous studies suggested accelerated periodontal destruction around teeth with occlusal trauma and increased mobility, however, the evidence is lacking. Recent animal studies found that occlusal trauma increased osteoclastic activity and alveolar bone loss. One possible mechanism suggested for the progression of periodontal destruction with occlusal trauma is that tooth mobility creates a subgingival environment conducive to overgrowth by periodontal pathogens. However, the association of occlusal trauma and subgingival microbiota was not evaluated in previous studies. Therefore, present study aimed to evaluate subgingival dental plaque components and compare with healthy individuals and periodontitis patients without occlusal trauma. ;

Related Conditions & MeSH terms

• Chronic Periodontitis
• Hypoxia
• Occlusal Trauma
• Periodontitis
• Wounds and Injuries

• NCT number: NCT03621891
• Study type: Observational
• Source: Tokat Gaziosmanpasa University
• Status: Completed
• Start date: May 1, 2016
• Completion date: May 1, 2017