The Effect of Aerobic Interval Training on Obstructive Sleep Apnea

Obstructive Sleep Apnea Syndrome Clinical Trial

Official title:

The Effect of Aerobic Interval Training on Obstructive Sleep Apnea, Cardiovascular and Pulmonary Function in Obese Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01215617
• Other study ID #: 2010/1539-5
• Secondary ID: 20101539-2
• Status: Completed
• Phase: N/A
• First received: October 4, 2010
• Last updated: March 28, 2017
• Start date: October 2010
• Est. completion date: October 2013

Study information

• Verified date: March 2017
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate if 3 months of interval training improves obstructive sleep apnea in obese patients diagnosed with moderate to severe obstructive sleep apnea. The working hypothesis is that 3 months of 3 weekly aerobic interval training sessions improve obstructive sleep apnea and sleep quality in obese patients.

Description:

Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive obstruction and collapse of the upper airway resulting in successive episodes of cessation of or decreased respiratory airflow, causing oxygen desaturation, awakening, loud snoring and daytime sleepiness in patients. Sleep apnea is frequently associated with co-morbidity such as obesity, diabetes, hypertension, the metabolic syndrome and cardiovascular disease. Lack of exercise is associated with OSAS severity, independent of body mass. Participation and motivation to exercise is low in OSAS patients, with less that one third of the patients reporting regular exercise routines. We aim to investigate if aerobic interval training improves OSAS in obese subjects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: October 2013
• Est. primary completion date: April 2013
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• BMI = 30 kg/M2

• Apne - hypopnea index (AHI) > 10

• No significant comorbidities

• Abel to exercise

Exclusion Criteria:

• Inability to exercise due to musculoskeletal conditions

• Known ischemic cardiovascular disease

• Drug abuse

• Mental illnesses

Related Conditions & MeSH terms

• Apnea
• Obstructive Sleep Apnea Syndrome
• Sleep Apnea Syndromes
• Sleep Apnea, Obstructive

Intervention

Behavioral:
• Aerobic Interval training
Treadmill walking or running - 3 times per week for 3 months. The interval training session consists of 10 minutes warm up and continues with 4 x 4 minutes high intensity intervals at 90-95% of maximal heart rate. Training intensity will be supervised through the use of Polar pulse monitors and the BORG scale of subjective perceived exhaustion.
• Control
Standard medical treatment

Locations

Country	Name	City	State
Norway	Norwegian University of Science and Technology	Trondheim

Sponsors (1)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology

Country where clinical trial is conducted

Norway, 

References & Publications (1)

Karlsen T, Nes BM, Tjønna AE, Engstrøm M, Støylen A, Steinshamn S. High-intensity interval training improves obstructive sleep apnoea. BMJ Open Sport & Exercise Medicine 2(1): http://dx.doi.org/10.1136/bmjsem-2016-000155

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Apnea-hypopnea index change	Measured by Polysomnography	Baseline, 3 and 6 months
Secondary	Sleep quality	Epworth Sleepiness Scale	Baseline, 3 and 6 months