Clinical Trials Logo

Clinical Trial Summary

This double-blind, randomized controlled trial will evaluate the use of nasal corticosteroids for the treatment of the childhood obstructive sleep apnea syndrome (OSAS). Efficacy, duration of action and side-effects will be determined.


Clinical Trial Description

Several studies have suggested that Nasal corticosteroids (NCS) or leukotriene antagonists may be effective in the treatment of childhood OSAS. However, these studies have been limited by factors such as small size, lack of randomization and blinding, short-term follow-up, involvement of children with only very mild OSAS, and/or lack of stratifying for the presence of atopy. Therefore, investigators will plan a randomized controlled trial evaluating the efficacy and safety of NCS vs placebo in children with mild to moderate OSAS. The overall hypothesis is that NCS will be safe and efficacious in the treatment of mild to moderate childhood OSAS, particularly in children with asthma/atopy, but will require ongoing maintenance therapy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02180672
Study type Interventional
Source Children's Hospital of Philadelphia
Contact
Status Completed
Phase Phase 3
Start date September 2014
Completion date October 30, 2021

See also
  Status Clinical Trial Phase
Withdrawn NCT05164211 - Didgeridoo Treatment to Improve Pharyngeal Compliance in Obstructive Sleep Apnea-hypopnea Syndrome in Children N/A
Active, not recruiting NCT05049928 - m-Rehab OSA : Impact of a Telerehabilitation Program Associated With CPAP on Severity Markers of Obstructive Sleep Apnea Syndrome N/A
Not yet recruiting NCT04538274 - Trained Patient Involvement to Promote the Resumption of CPAP in Patients Who Have Discontinued Its Use N/A
Completed NCT02967367 - Reliability of Consumer Sleep Trackers in Patients Suffering From Obstructive Sleep Apnea Syndrome N/A
Completed NCT02995837 - CBF and Childhood OSAS
Recruiting NCT01561677 - Consequences of Obstructive Sleep Apnea Syndrome (OSAS) After Ischemic Subtentorial Stroke. N/A
Completed NCT01193738 - Osteopathy and Obstructive Sleep Apnea Syndrome N/A
Completed NCT01808508 - Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome N/A
Completed NCT01090297 - Continuous Positive Airway Pressure (CPAP) Mode Impact on Clinical Blood Arterial Pressure N/A
Completed NCT00801671 - Russian Study of the Effect of Continuous Positive Airway Pressure (CPAP) in Hypertension Phase 3
Completed NCT00850876 - Heated Humidified Continuous Positive Airway Pressure and Nasal Physiology N/A
Completed NCT02085720 - Prevalence of OSAS in Chinese Elderly and Its CPAP Compliance N/A
Recruiting NCT00874913 - Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) N/A
Completed NCT00156442 - A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate N/A
Completed NCT00222963 - Pilot Study to Assess the Effectiveness of Tonsil and Adenoidectomy (T+A) in Overweight Children and Adolescents N/A
Withdrawn NCT00156455 - Sleep Disordered Breathing in Children With Single Ventricle Physiology N/A
Completed NCT01045499 - LAGB as a Treatment for Morbid Obesity in Adolescents N/A
Withdrawn NCT02559427 - SPA Therapy in the Treatment of Sleep Apnea Syndrome N/A
Completed NCT02522819 - Feasibility Evaluation of CPAP in the Treatment of Obstructive Sleep Apnea Synchrone in the Acute Phase of Stroke N/A
Completed NCT01215617 - The Effect of Aerobic Interval Training on Obstructive Sleep Apnea N/A