Obstructive Lung Diseases Clinical Trial
Official title:
Prevention of Post-exercise Muscle Fatigue Using a Non Invasive Ventilation and Effect on Exercise Training in Severe Patients With COPD. QUADRIVEND Study
In patients with severe Chronic Obstructive Pulmonary Disease (COPD), exercise tolerance is
severely impaired due to a ventilatory limitation, levelling off the intensity of exercise.
This reduces the physiological benefit of pulmonary rehabilitation. In these patients, it is
then proposed to add an Inspiratory Pressure Support (IPS) in order to increase the intensity
and the duration of every training session. In a preliminary study, the investigators showed
that IPS applied during an exhaustive cycling exercise allowed to prevent the onset of
post-exercise quadriceps fatigue evaluated by the endurance time to isotonic quadriceps
contractions (TlimQ).
The aim of this study is to determine the relationship between the prevention of
post-exercise fatigue (TlimQ) and the change in training load (intensity x time x number of
sessions) during a pulmonary rehabilitation programme. At the beginning of the training
programme, 25 patients will be evaluated for TlimQ after a cycling exercise (70% maximal
workload) with and without IPS in random order. The training load was then monitored at every
exercise session of the programme.
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