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Pre-treatment With Methylene Blue Prevent Peri-operative Reduced Systemic Vascular Resistance

Obstructive Jaundice Clinical Trial

Official title:
The Preventive Effects of Pre-treatment With Methylene Blue for Vascular Paralysis of the Patients With Obstructive Jaundice During Operation

Clinical Trial Summary

To explore the effects of pre-treatment with methylene blue on reduced perioperative vascular resistance in patients with obstructive jaundice.

Clinical Trial Description

Hemodynamic characteristics of patients with obstructive jaundice are high cardiac output, low peripheral vascular resistance. The molecular basis for this feature is the increased production of NO. Methylene blue can increase peripheral resistance, the mechanism is: methylene blue is an oxidoreductase inhibitor, can inhibit the increased production of NO in the vascular endothelium, thereby increasing peripheral vascular resistance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03406676
Study type Interventional
Source Southwest Hospital, China
Contact Ning Jiaolin, Doctor
Phone 0086-15808014085
Email Njiaolin1976@126.com
Status Recruiting
Phase N/A
Start date August 1, 2017
Completion date October 30, 2018
View Details
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