Obstructive Jaundice Clinical Trial
Official title:
Self Expanding Metal Stents (SEMS) or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors.
Patients with obstructive jaundice due to periampullary tumor can temporarily be relieved of
their jaundice with transpapillary stenting at endoscopic retrograde
cholangio-pancreatography (ERCP) prior to operation. Usually plastic stents are used.
Hypothesis: Self expanding metallic stents offer a be a better alternative for preoperative
stenting in patients with obstructive jaundice due to periampullary tumour obstruction.
Patients who present with obstructive jaundice and have a periampullary tumor and where the patient seems to be in good condition for surgical resection are offered the opportunity to become randomized to either endoscopic drainage with self expanding metallic or plastic stents. Before randomization they are informed about the study details and have to give their consent to participate. The metallic as well as plastic stents are standard commercially available stents. Within four weeks after stent placement the patient will be operated and the following parameters will be evaluated: quality of life, clinical symptoms and lab tests. At the operation the surgeon will make an evaluation of the inflammatory reaction in the area of the bile ducts. A culture from the bile is sampled close to the area where the anastomosis will be sutured. A tissue sample is also taken from the bile ducts to evaluate inflammation. A Lymph node is also sampled for the same reason. The surgeon also evaluates the difficulty with which the stent had to be removed. Postoperative complications are monitored in line with the regular routines at the clinic. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01506115 -
Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma
|
N/A | |
Completed |
NCT00409864 -
Endoscopic Versus Percutaneous Drainage For Hilar Block in Gall Bladder Cancer
|
N/A | |
Not yet recruiting |
NCT06093048 -
Endoscopic Retrograde Cholangiopancreatography In Patients Older Than 65Years Old With Obstructive Jaundice: Efficacy And Outcome
|
N/A | |
Completed |
NCT02468076 -
Radiofrequency Ablation for Biliopancreatic Malignancy
|
Phase 2 | |
Not yet recruiting |
NCT03491254 -
Investigating the Efficacy and Safety of the Combination Treatment of Huaier Granule and Biliary Drainage for MOJ
|
||
Recruiting |
NCT02797665 -
Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids
|
N/A | |
Recruiting |
NCT01367821 -
Immune Function in Patients With Obstructive Jaundice
|
N/A | |
Recruiting |
NCT06456476 -
Patients With Obstructive Jaundice In Sohag University Hospital
|
||
Completed |
NCT04385147 -
Advanced Endoscopy During COVID-19
|
||
Completed |
NCT05155475 -
Endoscopic Ultrasound Evaluation of the Common Bile Duct in Patients With Obstructive Jaundice Due to Bilio-pancreatic Malignancies (ECCO Trial)
|
||
Recruiting |
NCT03133026 -
Cholangioscopic Assessment of Occluded Biliary Stent and Role of Biliary Radiofrequency Ablation
|
N/A | |
Recruiting |
NCT01438385 -
Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders
|
N/A | |
Completed |
NCT01191814 -
Comparison of Metal and Plastic Stents for Preoperative Biliary Decompression
|
N/A | |
Recruiting |
NCT05246176 -
Ultrasonography as a Single Tool for Guided Percutaneous Transhepatic Biliary Drainage in Obstructive Jaundice
|
N/A | |
Recruiting |
NCT03977779 -
Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis
|
N/A | |
Completed |
NCT04823832 -
Endoscopic Versus Percutaneous Biliary Drainage for Resectable Pancreatic Head Cancer
|
N/A | |
Completed |
NCT03376945 -
Application of n-3 Fatty to Patient of Jaundice
|
N/A | |
Completed |
NCT03510754 -
Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP
|
||
Not yet recruiting |
NCT01688375 -
The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice
|
Phase 2 | |
Recruiting |
NCT05928286 -
Remaxol® Used in the Treatment of Patients With Gallstone Disease Complicated With Obstructive Jaundice
|