Acute Respiratory Distress Syndrome Clinical Trial
Official title:
Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients in an Urban Low-Resource Setting (LUSIP) - an Observational Study in Sierra Leone
This study aims at describing the frequency, timing and type of pulmonary complications detected with lung ultrasound in critically-ill parturients in admitted to a high-dependency unit in Freetown, Sierra Leone.
Rationale: The three big 'killers' in parturients, peripartum hemorrhage, sepsis and
pre-eclampsia all predispose to pulmonary complications. These complications affect
management before, during and after the primary obstetric problem has been solved. A timely
diagnosis and thorough follow-up of pulmonary complications may benefit parturients. Lung
ultrasound (LUS) is a point-of-care imaging bedside tool increasingly used in the critical
care setting that may prove useful in parturients.
Objective: To describe frequency, timing and type of pulmonary complications detected with
LUS in critically ill parturients in a high-dependency unit (HDU), and to determine the
association with outcome.
Hypotheses: Pulmonary complications detected by LUS are frequent in parturients admitted to a
HDU in a resource-limited setting, and are associated with hospital mortality.
Study design: A prospective observational study. Study population: Critically ill parturients
admitted to the HDU of the Princess Christian Maternity Hospital (PCMH) in Freetown, Sierra
Leone.
Sample size: No formal sample size calculation is performed. Based on current rates of
admissions to the HDU of the PCMH the investigators expect to perform LUS in at least 125
patients.
Methods: A trained physician performs all 12-region LUS investigations. LUS is performed at
admission, after 24 and 48 hours, and when a patient's respiratory condition deteriorates.
LUS findings are reported using a standardized semi-quantitative visual LUS scoring method.
Main study parameters/primary endpoints: The proportion of critically ill parturients
admitted to the HDU of the PCMH with pulmonary complications detected by LUS, including
interstitial syndrome, pulmonary consolidation, and pleural effusion.
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