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Obsessive-Compulsive Disorder clinical trials

View clinical trials related to Obsessive-Compulsive Disorder.

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NCT ID: NCT04813224 Recruiting - Depression Clinical Trials

Intervention Through EMDR and CBT With Women Victim of Childhood Sexual Abuse. A Randomized Controlled Trial.

Start date: April 16, 2021
Phase: N/A
Study type: Interventional

This study evaluates the effectiveness of two types of therapy for the treatment of sexual abuse psychological impact on a sample of Spanish women. The participants will receive first Trauma-Focused Cognitive Behavioral Therapy and Eye Movement Desensitization and Reprocessing treatments in order to observe the impact on symptoms of Posttraumatic Stress Disorder, somatization, obsessive-compulsive symptoms, anxiety, aggressiveness and dissociate symptoms.

NCT ID: NCT04806516 Active, not recruiting - Clinical trials for Obsessive-Compulsive Disorder

Phase II Adaptive Deep Brain Stimulation for Obsessive-Compulsive Disorder

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

This research study is for participants that have been diagnosed with intractable Obsessive -compulsive disorder (OCD). OCD is a persistent and oftentimes disabling disorder marked by unwanted and distressing thoughts (obsessions) and irresistible repetitive behaviors. OCD affects 2-3% of the US population, and is responsible for substantial functional impairment and increased risk of early death. The only established first-line treatments for OCD are cognitive-behavioral therapy (CBT) with exposure and response prevention and certain medications. About 30-40% of patients fail to respond and few experience complete symptom resolution. Up to 25% of patients have difficulty tolerating CBT and the risk of relapse after therapies remains large. For the most severe cases, neurosurgery (surgery in the brain), has long been the option of last resort. In this study the investigators want develop an adaptive Deep Brain Stimulation (aDBS) system to use in subjects with intractable (hard to control) OCD. Deep brain stimulation (DBS) remains investigational for OCD patients and is not considered standard therapy. DBS involves the surgical implantation of leads and electrodes into specific areas of the brain, which are thought to influence the disease. A pack implanted in the chest, called the neurotransmitter, keeps the electrical current coursing to the brain through a wire that connects the neurotransmitter and electrodes. It is believed DBS may restore balance to dysfunctional brain circuitry implicated in OCD. The goal of this study is to enhance current approaches to DBS targeting in the brain and to use a novel approach to find a better and more reliable system for OCD treatment. This current research protocol will focus on the completion of Phase II which will implant the RC+S system with ECoG paddles in 5 subjects.

NCT ID: NCT04786548 Active, not recruiting - Clinical trials for Obsessive-Compulsive Disorder

Neuroinflammation in Patients With OCD

Start date: April 1, 2021
Phase: Phase 2
Study type: Interventional

The goal of this study is to examine whether measurements of inflammation from brain scanning and blood tests can predict how much benefit patients with obsessive-compulsive disorder (OCD) will have from treatment with an anti-inflammatory medication, celecoxib, when adding to ongoing medication-based treatment for OCD.

NCT ID: NCT04777292 Completed - Clinical trials for Obsessive-Compulsive Disorder

ESTOCMA: Mental Health Application for Enhancing Mental Health Literacy About Obsessive-compulsive Disorder

ESTOCMA
Start date: December 21, 2021
Phase: N/A
Study type: Interventional

The aim of the study is to analyze the efficacy of a mobile health application (app) designed to increase mental health literacy, help seeking attitudes and reduce stigma associated with obsessive-compulsive disorder. A randomized controlled trial with crossover design will be carried out in non-clinical population to assess pre-post changes in levels mental health literacy, help seeking attitudes and stigma through app completion (an estimation of 10 days). Moreover, the stability of the changes will be tested at 3 months. Participants from community will be randomly assigned to one of two conditions: undertaking immediate-use or delayed use. We hypothesized that after using the app, participants will have a greater knowledge about obsessive-compulsive disorder, will be more prone to ask for help in case of showing OCD symptoms, and will show lower stigma attitudes and social distance.

NCT ID: NCT04775875 Enrolling by invitation - Clinical trials for Obsessive-Compulsive Disorder

The Use of Transcranial Ultrasound Treatment of Obsessive-Compulsive Disorder

Start date: December 1, 2020
Phase: N/A
Study type: Interventional

The primary objective of this study is to determine the safety and efficacy of ultrasound as a treatment for Obsessive Compulsive disorder.

NCT ID: NCT04730011 Recruiting - Clinical trials for Obsessive-Compulsive Disorder

Short and Intensive Treatment of Children and Adolescents With Obsessive-Compulsive Disorder

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Obsessive-compulsive disorders are very damaging illnesses; they can already appear in childhood and adolescence and become extremely chronic. With an average prevalence from 1-3%, they are among the most common psychiatric disorders in children and adolescents. 40% of diagnosed children and young adults display persistent and increasingly chronic symptoms and O-C disorders are highly complex syndromes with broadly varying manifestations. They arise from obsessive thoughts (ideas/thoughts or impulses, often senseless or tortured, that impose themselves or intrude) and obsessive behavior (ritualized patterns that must be frequently repeated).

NCT ID: NCT04723485 Recruiting - Clinical trials for Obsessive-compulsive Disorder

Evaluation Study: Obsessive-compulsive Disorders in Childhood and Young Adulthood

Start date: May 1, 2020
Phase:
Study type: Observational

Obsessive-compulsive disorders are very damaging illnesses that can already manifest in childhood and adolescence. With an average prevalence from 1 - 3%, they are one of the most frequently diagnosed psychiatric illness in these age groups. With the further use of data, the treatment success can be significantly improved; causal variables/predictors can be recognized, understood and taken carefully into account. The anticipated incremental knowledge will ultimately help children and young people with obsessive-compulsive disorders to receive faster and more effective treatment.

NCT ID: NCT04708834 Enrolling by invitation - Clinical trials for Obsessive Compulsive Disorder

Long-term Safety Study of Adjunctive Troriluzole in Subjects With Obsessive Compulsive Disorder

Start date: March 30, 2021
Phase: Phase 3
Study type: Interventional

The purpose of the study is to evaluate the long term safety and tolerability of troriluzole as adjunctive therapy in subjects with obsessive compulsive disorder (OCD).

NCT ID: NCT04701372 Completed - Clinical trials for Obsessive-Compulsive Disorder

Clinical Outcomes From NOCD Treatment of Obsessive-Compulsive Disorder Using Exposure and Response Prevention

Start date: January 1, 2020
Phase:
Study type: Observational

This is a naturalistic, observational study of individuals with obsessive-compulsive disorder who were treated with exposure and response prevention via video teletherapy, augmented with between-session support with text messaging and an online community forum.

NCT ID: NCT04693351 Recruiting - Clinical trials for Obsessive-Compulsive Disorder

Efficacy and Safety Study of Adjunctive Troriluzule in Obsessive Compulsive Disorder

Start date: January 29, 2021
Phase: Phase 3
Study type: Interventional

The study's purpose its to evaluate the efficacy and safety of troriluzole as adjunctive therapy compared to placebo in subjects with Obsessive Compulsive Disorder (OCD)