Obesity Clinical Trial
— BRANCH-POfficial title:
Preclinical Drug Discovery Informed by Public Health: Initiating a Step-Change in the Development of New Human Models
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop Nuclear Magnetic Resonance (NMR) spectroscopy in human clinical pathology. This is an instrument assessment study for point of care viability which will also result in enhanced patient care (pending their consent) in blood screenings and metabolic health data.
Status | Not yet recruiting |
Enrollment | 2000 |
Est. completion date | June 22, 2025 |
Est. primary completion date | January 1, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: All participants must satisfy ALL the following criteria at study entry: - A male or female aged equal to or greater than 18 years of age. - Participants who, in the opinion of the investigator, can and will comply with requirements of the study procedures (e.g. Attend routine standard of care testing clinics, agree to share routine standard of care test results for the purposes of research, etc.). - Participants who are able to provide written informed consent. Exclusion Criteria: If any of the exclusion criterion applies, the participant must not be included in the study: - Participants who are unable to provide consent due to incapacity. |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Willows Medical Centre | Leicester | Leicestershire |
Lead Sponsor | Collaborator |
---|---|
Willows Health | Nottingham Trent University |
United Kingdom,
Percival BC, Grootveld M, Gibson M, Osman Y, Molinari M, Jafari F, Sahota T, Martin M, Casanova F, Mather ML, Edgar M, Masania J, Wilson PB. Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models. High Throughput. 2018 Dec 27;8(1). pii: E2. doi: 10.3390/ht8010002. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Signal to Noise | An >0.97 (or 97%) area under the receiver operating characteristic (AUROC) of benchtop Nuclear Magnetic Resonance versus current Point of Care (POC) testing sensitivity/specificity in conditional classification of samples. | PhD study duration (Final Submission Date: 22 June 2025) |
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