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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05030636
Other study ID # CERC-20-049-P
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date September 15, 2021
Est. completion date August 2024

Study information

Verified date August 2021
Source Université de Montréal
Contact Marie-Ève Mathieu, Ph.D
Phone (514) 343-6737
Email me.mathieu@umontreal.ca
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The main objective of this research project is to assess the impact of the timing of exercise on sensory perception, more specifically on taste and smell. Also, the investigators want to identify the optimal exercise timing scenario that maximizes the short-term anorexigenic effect of exercise (i.e. decrease in energy intake at the meal following the exercise session) in each group of teenagers. Hypothesis: exercise immediately before a meal (EX->MEAL) will be the most efficient scenario, and will show a larger impact on males individuals and people who suffer obesity. Subsequently, the investigators want to understand the impacts of exercise on lifestyle habits (i.e. sleep and sedentariness). For the realization of this research project, the investigators plan to recruit approximately 144 participants, boys and girls with normal weight/obesity, aged 12 to 17 years. Of these participants, half will be male. There are two different exercise timings (i.e. performed at 9:30 am and 11:00 am using a treadmill to test the maximal aerobic capacity) and one sedentary control condition. Participants will take part in 3 experimental visits in a random order (~5 hours/visit at LAPS-UdeM + 24h of real-life monitoring). Appetite sensations, energy intake (i.e. total and macronutrient), activity monitoring using actigraphy, hormonal (i.e. anorexigenic and orexigenic) and chemosensory (i.e. cortical response to taste and smell stimulations) response will be monitored in the laboratory and/or remotely. This project will measure acute response in laboratory and real-life settings.


Description:

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Study Design


Related Conditions & MeSH terms


Intervention

Procedure:
Acute moderate to vigorous exercise performed at a specific moment of the day
Treadmill (30 minutes) at 70% of maximal aerobic capacity

Locations

Country Name City State
Canada Université de Montréal Montréal Quebec

Sponsors (2)

Lead Sponsor Collaborator
Université de Montréal Canadian Institutes of Health Research (CIHR)

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Primary Energy intake at lunch Obtained using an ad libitum meal 30 minutes
Primary Physical activity habits outside the laboratory Time spent in moderate-to-vigorous intensity. 24 hours
Primary Eating habits outside the laboratory Ambulatory monitoring of food provided that is eaten (kcal total) 24 hours
Primary Sedentary activity habits outside the laboratory Time spent in sedentary activities 24 hours
Primary Sleep activity habits outside the laboratory Time spent sleeping at night 24 hours
Secondary Chemosensory response - Taste Taste event-related potential (latency, duration and amplitude) using EEG Within the 30 minutes devoted to chemosensory testing, prior to the meal at noon.
Secondary Circulating concentration of PYY orexigenic hormonal level Within the 30 minutes devoted to chemosensory testing, prior to the meal at noon.
Secondary Chemosensory response - Smell Smell event-related potential (latency, duration and amplitude) using EEG Within the 30 minutes devoted to chemosensory testing, prior to the meal at noon, and in the 2 hour period following meal.
Secondary Circulating concentration of GLP1 Orexigenic hormonal level Within the 30 minutes devoted to chemosensory testing, prior to the meal at noon, and in the 2 hour period following meal.
Secondary Circulating levels of ghrelin Anorexigenic hormonal levels Within the 30 minutes devoted to chemosensory testing, prior to the meal at noon, and in the 2 hour period following meal.
Secondary Oxytomodulin Orexigenic hormonal levels. Within the 30 minutes devoted to chemosensory testing, prior to the meal at noon, and in the 2 hour period following meal.
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