Home-Based HIT in Obese Individuals

Obese Clinical Trial

Official title:

Effects of a 12-Week Home-Based High-Intensity Interval Training Programme in Obese Individuals With Elevated Cardiovascular Disease Risk: A Pilot Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03557736
• Other study ID #: Home-HIT
• Status: Completed
• Phase: N/A
• Start date: March 9, 2015
• Est. completion date: January 30, 2018

Study information

• Verified date: June 2018
• Source: Liverpool John Moores University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aims to investigate the efficacy of a novel home-based high-intensity interval training (Home-HIT) intervention in obese individuals, with elevated cardiovascular disease (CVD) risk. It was hypothesised that Home-HIT would 1) have high adherence to the prescribed exercise intensity (compliance), 2) improve markers of CVD risk, and 3) lead to favourable skeletal muscle adaptations.

Description:

The applicability of current high intensity interval training (HIT) protocols to the sedentary obese population has been disputed by public health experts. Existing HIT interventions have been successful only under optimal conditions with high levels of supervision and specialised equipment, creating further barriers to exercise in those most in need. We aimed to eliminate many of these barriers by modifying existing HIT protocols to create a new home-based HIT (Home-HIT) intervention tailored to individuals with low fitness and mobility. It was hypothesised that Home-HIT would 1) have high adherence to the prescribed exercise intensity (compliance) and 2) improve markers of cardiovascular disease (CVD) risk. 32 Obese adults with at least 3 additional CVD risk factors (age 36±2 y; BMI 34.3±0.8 kg∙m-2; VO2peak 24.6±1.0 ml∙kg∙min-1), completed one of three 12-week training programmes 3x/week: Home-HIT (n=9); Laboratory-based supervised HIT (Lab-HIT; n=10) or home-based moderate intensity continuous training (Home-MICT; n=13). Adherence and compliance were monitored online in almost "real time" using a heart rate (HR) monitor and mobile app. The Home-HIT group completed 4 progressing to 8 1min intervals interspersed with 1min of rest in an unsupervised place of their choosing. The intervals were composed of simple bodyweight exercises that required no equipment. Changes in VO2peak, insulin sensitivity, body composition, flow-mediated dilation (FMD) and aortic pulse wave velocity (PWV) were assessed. Muscle biopsies were taken to assess changes in capillarisation, mitochondrial density, intramuscular triglyceride (IMTG) content and eNOS and GLUT4 protein expression using quantitative immunofluorescence microscopy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: January 30, 2018
• Est. primary completion date: July 15, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• obesity (BMI >30 kg/m2)

• age 18-55

Exclusion Criteria:

• diagnosed CVD and other contraindications to participate in an exercise intervention

• BMI <30 kg/m2

Related Conditions & MeSH terms

• Obese

Intervention

Behavioral:
• Training mode
type of exercise training completed for 12 weeks

Locations

Country	Name	City	State
United Kingdom	Liverpool John Moores University	Liverpool	Merseyside

Sponsors (1)

Lead Sponsor	Collaborator
Liverpool John Moores University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change in aerobic fitness	change in maximal aerobic capacity following the training	change in baseline aerobic fitness at 12 weeks
Primary	Adherence and compliance to the exercise training intervention	Session completion rate (adherence) and ability to meet target heart rates (compliance)	adherance and compliance to the training over the 12 weeks
Secondary	change in baseline FMD	endothelial function measured using flow-mediated dilation (FMD)	change in baseline FMD at 12 weeks
Secondary	change in vascular stiffness	change in vascular stiffness with training	change in baseline vascular stiffness at 12 weeks
Secondary	change in body fat percentage	change in body fat percentage using DXA with training	chage in baseline body fat percentage at 12 weeks