Nutritional Requirements Clinical Trial
— LoDoSeOfficial title:
Predicting Dietary Selenium Needs to Achieve Target Blood Selenium Levels
Verified date | May 2018 |
Source | USDA Grand Forks Human Nutrition Research Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study, we will evaluate the effectiveness of several doses of oral selenomethionine in raising biomarkers of selenium status including plasma selenium concentrations.
Status | Completed |
Enrollment | 262 |
Est. completion date | September 2007 |
Est. primary completion date | September 2007 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - able to swallow capsules - body mass index less than 40 Exclusion Criteria: - Pregnancy - Chronic liver or kidney disease - taking medication that might affect liver and/or kidney - blood pressure 140/90 or higher - already taking more than 50 micrograms of selenium |
Country | Name | City | State |
---|---|---|---|
United States | USDA Grand Forks Human Nutrition Research Center | Grand Forks | North Dakota |
Lead Sponsor | Collaborator |
---|---|
USDA Grand Forks Human Nutrition Research Center | National Cancer Institute (NCI) |
United States,
Jackson MI, Combs GF Jr. Selenium and anticarcinogenesis: underlying mechanisms. Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):718-26. doi: 10.1097/MCO.0b013e3283139674. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluation of effectiveness of consuming oral doses of L-selenomethionine in raising plasma selenium concentrations | Baseline, and after 3, 6, 9, and 12 months of supplementation | ||
Secondary | Biomarkers of selenium status will be determined in urine, buccal cells, and plasma. White blood cells will be analyzed to identify DNA damage, reflecting the degree of oxidative damage and evaluate the status of antioxidant repair mechanisms. | Baseline and after 12 months of supplementation |
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