Clinical Trials Logo

Clinical Trial Summary

Older patients often suffer from multiple illnesses that require acute hospitalization. The goal of medical work is not only to save lives and heal acutely ill people but also to maintain physical fitness and self-sufficiency. In acutely hospitalized patients, the investigators often observe a decrease in muscle mass and strength, a deterioration in overall fitness with the need for long follow-up care, and sometimes permanent help with normal daily activities. An important part of the treatment of every acute patient is the emphasis on adequate nutrition and physical activity. The aim of this study is to determine the most appropriate intensity of exercise and diet that will be best for acute patients and will lead to the maintenance/improvement of physical fitness and thus shorten the length of hospitalization.


Clinical Trial Description

The goal of daily medical work is not only to save lives and cure acutely ill patients but also to maintain quality of life, minimize the risk of complications, and, in the ever-growing population of geriatric patients, to maintain functional ability and self-sufficiency. Acute diseases of the internal type are almost always associated with catabolism leading to proteolysis and exacerbation of malnutrition. Patients are then often observed to have loss of muscle strength and muscle mass, deterioration of fitness, and in geriatric patients, who often have limited functional reserve and loss of self-sufficiency with the need for long follow-up care and sometimes permanent assistance with activities of daily living. In addition to treating the disease itself, it is important to provide adequate nutrition and to maintain muscle strength and subsequent self-sufficiency by activating patients and providing optimally targeted physiotherapy. Studies demonstrating the effect of intensive rehabilitation are very heterogeneous and often performed on a relatively small number of subjects. Also, the results of these studies and their meta-analyses are inconclusive. It cannot be clearly stated based on the current scientific knowledge that intensive rehabilitation influences important endpoints such as in-hospital mortality, length of hospital stay, or the incidence of nosocomial infections. Early rehabilitation in acutely ill patients does influence muscle mass, but these effects are rather short-term.3 The effect of nutrition itself, or of individual nutrients (vitamin D, hydroxymethyl butyrate, etc.) is well known, and recommendations for nutrition have been developed based on this scientific knowledge. There is very limited evidence for the benefit of combining intensive rehabilitation and nutrition at the same time. The investigators know from available work that this intervention increases muscle mass and improves self-sufficiency. A very important and still evolving area of medicine is the gut microbiome. The number of bacteria in our digestive tract is approximately the same as the number of cells in our entire body. Some authors speak of the gut microbiome as a separate organ. Intestinal bacteria and their products have a proven effect on the immune system locally and systemically and influence a variety of metabolic processes (insulin sensitivity, appetite, lipid metabolism and storage, oxidative stress, influence on inflammation, etc.). Today, it is possible to talk about the gut-muscle axis and know that the composition of the gut microbiome influences muscle tissue and, conversely, physical activity has been shown to have a benefit on the gut microbiome. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05209763
Study type Interventional
Source University Hospital Ostrava
Contact Zdenek Lys, M.D.
Phone 1420736541342
Email [email protected]
Status Recruiting
Phase N/A
Start date March 10, 2022
Completion date December 31, 2025

See also
  Status Clinical Trial Phase
Completed NCT03438942 - Influence of Iron and Foliate Transporters on Bioavailability of These Micronutrients in the Organism N/A
Recruiting NCT04475666 - Replacing Protein Via Enteral Nutrition in Critically Ill Patients N/A
Recruiting NCT02763878 - Uncut Roux-en-y Anastomosis Reduce Postoperative Complication and Improve Nutritional Status After Distal Gastrectomy Phase 3
Completed NCT02402985 - Comparison of a Plant Protein Diet to a Animal Protein Diet Emphasized in Type 2 Diabetics N/A
Completed NCT02039596 - Nutritional Metabolomics: the Search for Dietary Exposure Variables N/A
Active, not recruiting NCT00996528 - Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) Phase 3
Recruiting NCT04170348 - Daily Vitamin D for Sickle-cell Respiratory Complications Phase 2
Recruiting NCT03843424 - Treatment Efforts Addressing Child Weight Management by Unifying Patients, Parents & Providers N/A
Completed NCT03440593 - Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients N/A
Not yet recruiting NCT05348590 - Phase-Germ Project: Muscle Mass and Phase Angle in Surgical Patient
Recruiting NCT04554758 - Comparative Analysis Between Sleeve Gastrectomy and Roux-en Y Gastric Bypass in Bariatric Operation N/A
Recruiting NCT04389424 - Relationship Between Body Composition, Food Consumption, and Micro and Macronutrients With Gene Expression in Breast Cancer
Completed NCT03772171 - Estimate for Dietary Intakes and Hemodialysis Patients
Completed NCT01708681 - Lean Seafood Intake and Postprandial Metabolism N/A
Completed NCT01211301 - Medifast 5 & 1 Plan N/A
Completed NCT01081587 - Preventing Malnutrition and Restoring Nutritional Status in Hospitalized Children N/A
Recruiting NCT03865706 - Inulin for Infections in the Intensive Care Unit Phase 2
Recruiting NCT05276752 - Short- and Long-term Health Adverse Outcomes Associated With Nutrition Disorders and Nutrition Related Conditions in Hospitalized Older People
Recruiting NCT03643341 - Family Healthy Living Early Intervention Program N/A
Not yet recruiting NCT03618329 - Effect of Prehabilitation on the Lean Mass Index (IMM) in ERAS PROGRAMM. N/A