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Nut Hypersensitivity clinical trials

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NCT ID: NCT01918657 Withdrawn - Peanut Allergy Clinical Trials

Walnut Oral Immunotherapy for Tree Nut Allergy

Start date: February 2014
Phase: N/A
Study type: Interventional

The purpose of this research study is to learn about the medical effects, safety, and how the Walnut Oral Immunotherapy (OIT) treatment affects your body (immune system). This type of immunotherapy involves giving increasing doses of walnut allergen to gradually build up a person's tolerance to walnut and at least one other tree nut. The goal of the study is to determine whether participants can tolerate (eat) walnuts and at least one other tree nut in their diet after stopping the study therapy.

NCT ID: NCT01834352 Withdrawn - Clinical trials for Nut Hypersensitivities

Walnut Oral Immunotherapy for Tree Nut Allergy

WOIT
Start date: November 2013
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine if walnut oral immunotherapy can be used in subjects allergic to tree nuts to decrease their tree nut allergy and induce changes in their immune system.

NCT ID: NCT01822353 Completed - Food Allergy Clinical Trials

The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults

Start date: January 2013
Phase: N/A
Study type: Interventional

In Finland, the estimated prevalence of physician-diagnosed food allergy in 1-4 year old children is 9%, and the most common allergen is milk. The overall food allergy has been reported to be 3.7%. Hen's egg allergy is among the most common food allergies in childhood. In addition, it predicts later development of allergic disease such as asthma. Most of the egg and milk allergy is transient and disappears in childhood. Currently, the standard of care for food allergy includes strict allergen avoidance. However, oral immunotherapy has been under investigation in children milk, egg, and wheat allergy. Previously, induction of clinical egg tolerance has been reported with egg oral immunotherapy in children aged from 3 to 13 years. In adults, strict avoidance is still the standard care but there is also growing interest in treatment of severe food allergy with oral immunotherapy or anti-IgE. The investigators aim to analyse the results of per oral immunotherapy treatment in severe IgE-mediated egg, milk, and nut allergy in adults. Could severe egg, milk and nut allergy be treated with oral immunotherapy treatment in stead of total allergen avoidance and could desensitization thus be achieved?

NCT ID: NCT01744990 Completed - Clinical trials for Nut Allergy in Children

Tree Nuts Allergies: Does a Single Nut Allergy Necessitate the Dietary Eviction of Other Tree Nuts?

ProNut
Start date: October 2012
Phase: N/A
Study type: Interventional

The aim of this study is to identify, based on standardized food provocation tests, which nuts allergic patients need a selective, or a complete dietary eviction of all kind of nuts (nuts being defined as peanut, all tree nuts, pine nut and sesame). The investigators postulate that predictive factors of multiple nut allergy are high specific immunoglobulin E level, positive skin tests and/or clinical markers, such as atopic dermatitis, presence of other food allergies or a history of a severe previous reaction

NCT ID: NCT01546753 Completed - Tree Nut Allergy Clinical Trials

Walnut Oral Immunotherapy for Tree Nut Allergy

WOIT
Start date: April 27, 2012
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine if walnut oral immunotherapy can be used in participants allergic to tree nuts to reduce tree nut allergy and induce changes in the participant's immune system.

NCT ID: NCT01502878 Completed - Nut Allergy Clinical Trials

Nut Allergy Study: Double-blind Challenge and Oral Desensitization

Start date: May 2011
Phase: N/A
Study type: Interventional

Nut sensitization in skin prick tests is common in areas, including Finland, where birch pollen is abundant. However, sensitization to nuts in skin prick test does not predict the possibility of allergic symptoms when nuts are ingested. In this study the investigators launch and perform double-blind placebo-controlled nut challenges and oral desensitization/ protocol to those with serious symptoms in the challenge. The efficacy and safety of the new oral desensitization program is the primary outcome. The effect of oral desensitization on bronchial hyperreactivity, eosinophilic airway inflammation, and quality of life are secondary outcomes.

NCT ID: NCT01070498 Completed - Food Allergy Clinical Trials

Trichuris Suis Ova in Peanut and Tree Nut Allergy

Start date: February 2010
Phase: Phase 1
Study type: Interventional

The goal of this study is to determine whether Trichuris suis ova, a potential immunomodulator, is safe in adults and children allergic to peanut or tree nuts.