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Clinical Trial Summary

Rationale: In cataract surgery, fragmentation of a hard nucleus requires relatively much ultrasound energy. It is suspected that the level of energy used is associated with the degree of corneal endothelial loss. Recently, it was demonstrated that with miLOOP (Zeiss Meditec) assisted nuclear fragmentation ultrasound energy can be substantially reduced. Objective: To compare miLOOP assisted cataract surgery and conventional surgery with respect to the energy needed for phacoemulsification and loss of corneal endothelial cells. Study design: Randomized, controlled trial. Study population: Patients with nuclear cataract of a grade ≥ 5. Intervention: Microinterventional endocapsular nuclear fragmentation. Main study parameters: Cumulative dispersed ultrasound energy (CDE) and endothelial cell loss.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT05736042
Study type Interventional
Source Oogziekenhuis Rotterdam
Contact Rene Wubbels
Phone +31104023430
Email r.wubbels@oogziekenhuis.nl
Status Recruiting
Phase N/A
Start date April 3, 2023
Completion date June 2025

See also
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Active, not recruiting NCT00825721 - Dose-Ranging Study of an Ophthalamic Solution in Patients With Loss of Visual Function Due to Age-Related Nuclear Cataract Phase 2
Completed NCT04975971 - A Retrospective Review of DEXTENZA 0.4 mg inseRt Following Corneal Transplant or Cataract Surgery