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JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation

Advanced Solid Tumor Clinical Trial

Official title:
A Phase 1/2, Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of JAB-21822 Monotherapy and Combination Therapy in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation

Clinical Trial Summary

This study is to evaluate the safety and tolerability of JAB-21822 monotherapy and combination therapy in adult participants with advanced solid tumors harboring KRAS G12C mutation.

Clinical Trial Description

The primary objective of this study is to evaluate the safety and tolerability of JAB-21822 monotherapy to determine the MTD and PR2D during Dose Escalation phase; then to evaluate preliminary antitumor activity when JAB-21822 administered alone and combination with cetuximab during Dose Expansion phase in adult participants with advanced solid tumors harboring KRAS G12C mutation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05002270
Study type Interventional
Source Jacobio Pharmaceuticals Co., Ltd.
Contact Huiqiang Wang, PhD
Phone 86 10 56315466
Email Huiqiang.wang@jacobiopharma.com
Status Recruiting
Phase Phase 1/Phase 2
Start date September 3, 2021
Completion date July 2025
View Details
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