Malnutrition Clinical Trial
Official title:
Immunocompetency and Nutritive Status in Inpatient Gero-Rehabilitation
Hospital-acquired infections can occur five times as frequently in rehabilitation patients than in other hospital admissions. We postulate that this high infection rate may be due to nutritional problems frequently experienced in these patients. In this study, we examine the role of nutrition in inpatient geriatric rehabilitation patients' immune function and infection rates.
Background:
Hospital-acquired infections can occur five times as frequently in rehabilitation patients
than in other hospital admissions. We postulated that this high infection rate may be due to
nutritional problems frequently experienced in these patients. In this study, we examined
the role of nutrition in inpatient geriatric rehabilitation patients' immune function and
infection rates.
Objectives:
We examined immunologic correlates of nutritional status in elderly veterans hospitalized
for extended periods of inpatient rehabilitation. We tested the hypotheses that geriatric
rehabilitation inpatients who receive standard clinical and dietary care: 1) experience
deficiencies in nutrients important to immune function while they are hospitalized; and 2)
those patients deficient in nutrients important for immune function experience higher
infection rates.
Secondary objectives included: 1) identifying nutritional and physiological factors that
might lead to immune function deficiencies and infection; and 2) developing a clinical
assessment model of malnutrition that can be used to assess immune function in geriatric
rehabilitation inpatients.
Methods:
In this descriptive cohort study, to test Hypothesis 1, we collected data to describe, over
time, in 100 non-acute elderly patients receiving longer-term inpatient rehabilitation care,
trends in and relationships among: 1) caloric, protein, and immunologically-relevant
micronutrient intake; 2) body composition, metabolism, and biochemical indices of
nutritional status; 3) humoral and cell mediated immunity; and 4) infection. To test
Hypothesis 2, we collected data to examine differences in infection rates in adequately
versus inadequately nourished patients. Secondarily, our study was conducted to examine the
relationship of patients' eating, their nutritional status, and their immune function over
time.
Status:
Project data collection activities have been completed. A total sample size of 100 patients
completed the study protocol. No study-related serious adverse events occurred during study
implementation. As declared above, while data analysis activities have been initiated as
planned, no study results or findings are ready to report at this time.
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Time Perspective: Prospective
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