Normal Tension Glaucoma Clinical Trial
Official title:
Measurement of the Effect of Gingko Biloba Extract on Ocular and Nailfold Blood-flow in Normaltension Glaucoma by Ocular Coherence Tomography Angiography and Nailfold Capillaroscopy
The purpose of this study is to evaluate the effect of Ginkgo biloba extract (GBE) on the number of blood vessels in the back of the eye as well as the amount of blood flow at the nailfold(where the fingernail meets the skin) of the 4th finger in the hand.This finger, along with the 5th finger, has the most transparent skin, which makes imaging a little easier. GBE is an over-the-counter pill, made from a natural powder taken from the Gingko (Maidenhair) tree, that is widely used. A technique called Optical Coherence Tomography Angiography (OCTA),will be used to measure the small blood vessels at the back of the eye, the macula (the area of sharpest vision), and the optic disc (the point at which the nerve fibers from the retina enter to form the optic nerve, which transmits visual impulses to the brain).
GBE has been reported to improve blood flow to the brain, eye, and extremeties(hands,
feet,etc.). .As with most supplements, GBE is neither regulated nor FDA approved.
A technique called Optical Coherence Tomography Angiography (OCTA),will be used to measure
the small blood vessels at the back of the eye, the macula (the area of sharpest vision), and
the optic disc (the point at which the nerve fibers from the retina enter to form the optic
nerve, which transmits visual impulses to the brain). This technique uses a camera, capable
of imaging the smallest vessels, so that their density (number) can be calculated by a
computer. This is being done to determine if there is disease causing increasing loss of
these vessels. The imaging is done by a widely used camera which does not contact the eye. It
simply uses visible light to measure the amount of blood vessels present in a determined area
in the back of the eye. Blood flow at the 4th finger nailfold (nailfold capillaroscopy; NFC)
is a standard technique, especially in rheumatology, performed by using a commercially
available light microscope which glides over the base of the fingernail and can image the
tiny capillaries in the nailfold. These images are recorded as videos from which the blood
flow can be analyzed by freely available software for the purpose of quantitative
measurements (amount of blood flow and blood flow velocity).
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