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Normal Tension Glaucoma clinical trials

View clinical trials related to Normal Tension Glaucoma.

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NCT ID: NCT04475900 Completed - Glaucoma Clinical Trials

Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics

EyeTwin
Start date: July 9, 2020
Phase:
Study type: Observational

The purpose of this study is the investigation of biomechanical properties of the cornea using computer-aided data analysis. Currently, it is known that keratoconus and glaucoma are ocular disease that are associated with biomechanical alterations of the cornea. Corneal ectasia, especially keratoconus, is a corneal disease that leads to an irreversible loss of visual acuity while the cornea becomes steeper, thinner and irregular. For these patients, surgical intervention (e.g. corneal cross-linking) is performed, in case of disease progression. In glaucoma, the information about corneal alterations serves in two ways, first, correct measurement of intra ocular pressure (IOP); second, early diagnosis of suspects before visual field defects are detectable. Especially, the Corvis ST is an air-puff tonometer that measures intraocular pressure, corneal thickness (CCT) as well as dynamic corneal response (DCR) parameters. Most of the DCR parameters are affected by IOP and CCT: Therefore, algorithm are needed to determine parameters without impact of IOP and CCT that are describe the biomechanical properties of the cornea.

NCT ID: NCT04014933 Completed - Healthy Clinical Trials

Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System

LSFG Repro
Start date: July 1, 2019
Phase:
Study type: Observational

In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.

NCT ID: NCT03387306 Completed - Clinical trials for Normal Tension Glaucoma

Serum Bilirubin Levels in Normal-tension Glaucoma

Start date: January 2010
Phase: N/A
Study type: Observational

Purpose: To analyze the relationship between normal-tension glaucoma (NTG) and serum bilirubin levels. Materials and Methods: This research included 38 patients with NTG and 38 healthy controls with similar age and sex distribution, for a total of 76 subjects. Serum samples were taken from all of the subjects, direct serum bilirubin, indirect serum bilirubin and the total serum bilirubin were measured.

NCT ID: NCT03323164 Completed - Clinical trials for Primary Open-angle Glaucoma

Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study

Start date: July 10, 2017
Phase: Phase 4
Study type: Interventional

This study evaluates the possible acute changes in peripapillary blood flow after instillation of antiglaucoma medications in patients with primary open angle glaucoma (POAG), normal tension glaucoma (NTG), or ocular hypertension (OHTN) using Optical Coherence Tomography (OCT) angiography.

NCT ID: NCT03106532 Completed - Clinical trials for Normal Tension Glaucoma

Evaluation of PHP-201 Ophthalmic Solution in Patients With Normal Tension Glaucoma

Start date: March 6, 2017
Phase: Phase 2
Study type: Interventional

Evaluation of the optimal dose for the efficacy in reduction of intraocular pressure and safety of PHP-201 ophthalmic solution in patients with normal tension glaucoma

NCT ID: NCT02863705 Completed - Clinical trials for Glaucoma, Open-Angle

Efficacy and Safety of COMBIGAN® in Korean Patients With Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG)

Start date: July 5, 2016
Phase: Phase 4
Study type: Interventional

The objective of this study is to evaluate the long-term efficacy and safety of COMBIGAN® (brimonidine tartrate/timolol malate) in patients only using COMBIGAN® (brimonidine tartrate/timolol malate) and also in patients who require additional IOP lowering with LUMIGAN® (bimatoprost) 0.01%.

NCT ID: NCT02863224 Completed - Ocular Hypertension Clinical Trials

Advanced Glycation End Products as a Biomarker for Accelerated Ageing

Start date: August 2016
Phase:
Study type: Observational

Globally primary open angle glaucoma (POAG) affects over 60 million people. The exact pathogenesis of POAG is poorly understood. A significant risk factor for glaucoma is advancing age. The rate of ageing is not the same in all age matched individuals. The concept of accelerated ageing suggests that the presence of a number of specific genetic, environmental or systemic risk factors may cumulate to accelerate the ageing process in some individuals and lead to the development of age-related disease. Understanding the factors that influence accelerated ageing is vital. Advanced glycation end products (AGEs) are a complex group of compounds that are naturally formed. They accumulate gradually with age in cells, tissues and blood vessels throughout the body where they adversely affect structure and function. Circulating AGE levels can be influenced by oxidative stress levels and dietary intake. Recent research has found that sustained exposure to high levels of circulating AGEs could be a major factor in the development of a number of chronic age-related degenerative disorders, including POAG. To date there have been few clinical studies that have been able to non-invasively explore the association between AGE levels and the development and progression of glaucomatous optic neuropathy (GON), or to explore the possible contribution that oxidative stress and dietary intake make to total tissue AGE levels in such patients. Furthermore little is understood about the relationship between AGE levels and retinal vascular function, a parameter known to be altered in GON that also could be influenced by AGE levels. The proposed study will aim to evaluate whether tissue-bound AGE levels are associated with parameters of retinal vascular function, oxidative stress, dietary intake and the presence of GON. Establishing this association could increase our understanding of the pathogenesis of GON and allow a new biomarker for accelerated ocular ageing to be realised

NCT ID: NCT02776449 Completed - Clinical trials for Normal Tension Glaucoma

Pressure Difference Between Brain and Eye: a Possible Cause to Normal Tension Glaucoma.

Start date: February 2016
Phase: N/A
Study type: Observational

The main aim of this study is to determine the trans-laminal cribrosa pressure difference (TLCPD) for normal tension glaucoma (NTG) patients from the brain and the eye in supine, upright and minor head down tilt positions. It is also to investigate the venous drainage system in the same body positions.

NCT ID: NCT01995136 Completed - Ocular Hypertension Clinical Trials

Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma

Start date: September 2013
Phase: Phase 4
Study type: Interventional

The purpose of this study is to investigate IOP reduction efficacy of travoprost 0.004% ophthalmic solution (TRAVATAN Z®) in subjects with normal tension glaucoma.

NCT ID: NCT01912599 Completed - Clinical trials for Normal-Tension Glaucoma

Pilot Study on Ambulatory Intraocular Pressure and Blood Pressure Monitoring in Glaucoma

Start date: July 2013
Phase: N/A
Study type: Interventional

Purpose: To study the feasibility of a larger study by determining the tolerability of measuring blood pressure (BP) and intraocular pressure (IOP) over 24 hours in an ambulatory fashion with automatic devices. Participants: 20 patients with moderate to severe normal tension glaucoma and 20 non-glaucomatous patients. Procedures (methods): Both BP and IOP will be measured automatically in each participant in an ambulatory fashion during a 24-hour period. BP will be monitored using an appropriately sized cuff Oscar 2 (Suntech Medical, Morrisville, NC), which will be placed by a person trained in ambulatory BP monitoring devices. The device will be set up to automatically inflate every 30 minutes during the day and every hour during the night to measure and record the BP. IOP will be measured using Sensimed Triggerfish contact lens (Sensimed AG, Lausanne, Switzerland); the measurements will be taken and recorded every 10 minutes. The contact lens will be inserted by eye doctors (investigators). Both monitoring devices will be removed the following day.