Clinical Trials Logo
  1. Home
  2. Noonan Syndrome
  3. NCT05761314

Solid Tumors in RASopathies — 4218  

Noonan Syndrome Clinical Trial

Official title:
Incidence and Molecular Pathogenesis of Solid Tumors in RASopathies

Clinical Trial Summary

RASopathies are a group of syndromes, caused by variants of genes involved in the regulation of the Ras/MAP/ERK pathway. This intracellular transduction pathway profoundly affects embryogenic development, organogenesis, synaptic plasticity and neuronal growth. RASopathies are characterized by multi-organ involvement, growth delay, premature aging and haemato-oncological manifestations. Based on evidences provided by literature, cancer screening protocols are applied in some individuals affected by RASopathies, even though detailed information about prevalence and molecular pathogenesis of such tumors is still not clearly elucidate.

Clinical Trial Description

To define the prevalence of solid (non-haematological) neoplasms in a monocentric cohort of patients affected by RASopathies To perform Next Generation Sequencing (NGS) analysis on tissue samples to preliminarily characterize the molecular pathogenesis of solid tumors in these patients' categories. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05761314
Study type Interventional
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Chiara Leoni, MD, PhD
Phone 0039063381344
Email chiara.leoni@policlinicogemelli.it
Status Recruiting
Phase N/A
Start date October 12, 2021
Completion date October 12, 2026
View Details
See also
  Status Clinical Trial Phase
Completed NCT01529944 - Genetic Testing of Noonan Subjects Previously Treated With Norditropin®. An Extension to Trial GHNOO-1658 Phase 3
Completed NCT00452725 - Effect of MAXOMAT ® on the Growth of Small Children to NOONAN's Syndrome Phase 3
Recruiting NCT04463316 - GROWing Up With Rare GENEtic Syndromes
Recruiting NCT06267807 - Lymphatic Phenotype in Noonan Syndrome Spectrum Disorders N/A
Enrolling by invitation NCT05308927 - French Registry of Children Treated With Norditropin® for Short Stature Associated With Noonan Syndrome
Recruiting NCT04395495 - RASopathy Biorepository
Completed NCT01529840 - Somatropin Effect on Linear Growth and Final Height in Subjects With Noonan Syndrome Phase 3
Recruiting NCT06355622 - Prevalence and Characterization of Pain in RASopathies N/A
Recruiting NCT05202210 - Constitution of a Biological Collection to Study the Pathophysiology in Noonan Syndrome
Completed NCT02713945 - Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome Phase 3
Recruiting NCT05361811 - Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial N/A
Completed NCT03435627 - Post Marketing Surveillance on Long-term Use With Norditropin® (Short Stature Due to Noonan Syndrome)
Recruiting NCT05723835 - A Research Study Looking at How Safe Somapacitan is and How Well it Works in Children Who Need Help to Grow - REAL 9 Phase 3
Completed NCT02486731 - Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes
Completed NCT01927861 - Investigating the Long-term Efficacy and Safety of Two Doses of NN-220 (Somatropin) in Short Stature Due to Noonan Syndrome Phase 3
Recruiting NCT04888936 - Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies
Recruiting NCT06331117 - Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies N/A
Completed NCT00960128 - Observational Prospective Study on Patients Treated With Norditropin® N/A
Terminated NCT00351221 - Research Study Using Recombinant Human Insulin-Like Growth Factor-1/Recombinant Human Insulin-Like Growth Factor Binding Protein-3 for Children With Noonan Syndrome Phase 2