Clinical Trials Logo

Clinical Trial Summary

This study intends to collect blood samples of adult healthy subjects, elderly healthy subjects and elderly patients with atrial fibrillation after taking dabigatran etexilate for pharmacokinetics and other studies, aiming to reveal the effect of dabigatran etexilate in Chinese elderly population. Pharmacokinetic profile and biomarker concentration levels; fecal samples were collected for gut microbiota studies to further explore potential mechanisms. The results of the study may provide reference for the precision medicine of dabigatran etexilate and other drugs in the elderly population or the development of new clinical drugs.


Clinical Trial Description

This study is a single-center, open-label clinical study, with adult healthy subjects, elderly healthy subjects and elderly patients with atrial fibrillation as the research subjects. Adult healthy subjects and elderly healthy subjects only take one 110 mg dabigatran etexilate capsule (low-dose specification in the instruction manual) orally. Elderly patients with atrial fibrillation take dabigatran etexilate according to routine medical treatment. Blood samples at 0 h(before dosing), 2 h, 6 h, 10 h and 24 h after dosing, and additional stool samples were collected. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05715658
Study type Interventional
Source Peking University Third Hospital
Contact Dongyang Liu
Phone (86)010-82266658
Email liudongyang@vip.sina.com
Status Recruiting
Phase N/A
Start date August 15, 2022
Completion date July 30, 2023

See also
  Status Clinical Trial Phase
Completed NCT05533788 - ABSK091 Food Effect Study in Healthy Subjects Phase 1
Active, not recruiting NCT05541653 - The IGNITE Study on Concentrated Investment in Black Neighborhoods N/A
Active, not recruiting NCT04097119 - HDL Function Dietary Supplement Safety and QOL N/A
Not yet recruiting NCT03549403 - Effects of Patient-centered Telephone Education in Day Surgery N/A
Enrolling by invitation NCT05404386 - Effect of Mobile Application on Urinary Incontinence N/A
Completed NCT05366348 - The Effects of Horse-back Riding on Core Muscles in Adolescents N/A
Completed NCT04005456 - Personalized Lifestyle Intervention for Improving Functional Health Outcomes Using N-of-1 Tent-Umbrella-Bucket Design N/A
Completed NCT04087525 - A Study to Evaluate the Pharmacokinetics and Safety of HIP1701 in Healthy Subjects Phase 1
Completed NCT05550610 - Evaluation of Mindfulness and Yoga in Basic Combat Training N/A
Completed NCT03311893 - Determine the Point of View of Society Society to Natural Orifice Surgeon N/A
Completed NCT04936373 - Quality of Life of Patients With Pregnancy Related VTE
Completed NCT03966625 - Serological Identification of Celiac Disease in Kids
Recruiting NCT05629351 - Prevalence of Sedentary Lifestyle, Pre-hypertension, and Obesity
Enrolling by invitation NCT03742128 - Health and Quality of Life Among Resettled Syrians in Norway
Completed NCT04648748 - Normative Data of Hand Grip Strength in Healthy Adult Pakistani Population
Completed NCT04616716 - A Food Effect Study of FMTN on Healthy Chinese Adult Subjects Phase 1
Recruiting NCT04766203 - Relative Energy Deficiency in Sport Multicenter Study N/A
Completed NCT03128671 - Family Automated Voice Reorientation Study N/A
Completed NCT05014958 - The Effect of Whole Body Vibration Training on Trunk Muscle Strength, Body Composition and Performance Parameters N/A
Completed NCT03828097 - The Effects of a Multi-vitamin Supplement in Adult Females N/A