Nonunion of Fracture of Fifth Metatarsal Clinical Trial
Official title:
A Prospective, Randomized, Double-Blind Study on Adjunctive Use of Pulsed Electromagnetic Fields in the Treatment of 5th Metatarsal Non-Union Fractures: Effect on Clinical Outcome and Growth Factor Synthesis
The purpose of this study is to analyze the effect of PEMF in surgical reconstruction of 5th metatarsal non-union fractures.
The investigators hypothesize:
1. That treatment of 5th metatarsal non-union fracture with PEMF will achieve earlier
resolution and/or higher success compared to surgery alone of 5th metatarsal non-union
fractures.
2. PEMF will stimulate increased expression of critical growth factors (i.e. BMP-2, BMP-4,
BMP-7 as well as TGFb, IGF-1, FGF-2 and VEGF) at the non-union site to facilitate
osseous healing of 5th metatarsal non-union fractures.
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